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TranscriptomicsAllele-specific expression in liver, hypothalamus and vomeronasal organ of Mus.m.musculus and M.m. domesticus
We performed RNaseq of liver, hypothalamus and vomeronasal organ crosses between inbred stains of M. m. domesticus (strain WSB/EiJ) and M. m. musculus (PWD/PhJ). We also sequenced RNA from the same tissues from parental M. m. musculus (PWD/PhJ).
ORGANISM(S): Mus musculus 
2015-02-10 | E-MTAB-3288 | biostudies-arrayexpress
TranscriptomicsExpression in hypothalamus of wild-derived mice M.m. domesticus
We sequenced hypothalamus RNA from 16 individuals from two wild-caught outbred M. m. domesticus populations that consisted of eight unrelated individuals each, from France and Germany
ORGANISM(S): Mus musculus domesticus 
2015-02-12 | E-MTAB-3304 | biostudies-arrayexpress
TranscriptomicsGene expression data from mouse postnatal brain development
In development, timing is of the utmost importance, and the timing of various developmental processes are often changed during evolution. We measured the timing of gene expression changes in the brains of two species of mice throughout postnatal development. Mus musculus and Mus spretus mice were br...
ORGANISM(S): Mus musculus 
2009-03-09 | E-GEOD-11528 | biostudies-arrayexpress
TranscriptomicsComparison of expression profiles of once and three time linearly amplified samples
In order to assess the impact of three rounds of linear amplification on the technical reproducibility of gene expression measurements, we performed twelve microarray experiments. We analysed mouse RNA from cortex, cerebellum and liver from one individual. One RNA sample of 5µg from each of the thr...
ORGANISM(S): Mus musculus 
2010-06-08 | E-GEOD-21389 | biostudies-arrayexpress
TranscriptomicsHuman Immune Response Dynamics - gene expression
We investigated changes in the human immune system following vaccination against H1N1 swine flu, to define the healthy immue response to vaccination, and to correlate it to cases of non-response and adverse events. Gene expression was measured twice before and twice after vaccination (week before/o...
ORGANISM(S): Homo sapiens 
2015-11-01 | E-MTAB-2313 | biostudies-arrayexpress
TranscriptomicsscRNA-seq of PBMC cells sorted into CD3+/CD19+ and CD3-CD19- buckets from Omenn syndrome patients and healthy controls
In this study, we sought to extend knowledge of lymphocyte development by studying patients with classical Omenn syndrome or T-B- SCID. to gain further insight into pathomechanism, we undertook single cell studies of cryopreserved peripheral blood mononuclear cells from patients with Omenn syndrome ...
ORGANISM(S): Homo sapiens 
2024-06-06 | E-MTAB-12283 | biostudies-arrayexpress
TranscriptomicsMapping T cell responses to native and neo- islet antigen epitopes in at risk and type 1 diabetes subjects
Gene expression and T cell receptor profiles from single cells from populations of T cells stimulated with islet autoantigenic peptides. CD4 T cells were stimulated with native (proinsulin, GAD fragments) or neo-antigen epitopes or flu vaccine (Pediacel). Activated cells (identified as CD19- CD3+ C...
ORGANISM(S): Homo sapiens 
2021-05-29 | E-MTAB-10323 | biostudies-arrayexpress
TranscriptomicsRNAseq of Tregs before and after treatment with Multipep
Intent: to investigate whether treatment of an individual with peptide immunotherapy using MultiPepT1De results in a change in the transcriptional profile of CD4+ regulatory T cells. Regulatory T cells (CD4+ CD25+ CD127lo) were isolated by flow cytometry cell sorting from cryopreserved PBMC from su...
ORGANISM(S): Homo sapiens 
2022-07-10 | E-MTAB-10756 | biostudies-arrayexpress
TranscriptomicsRNA sequencing of CD57+ and CD57- effector memory CD8 T cells in patients with type 1 diabetes
Type 1 diabetes is an autoimmune disease in which insulin-secreting β cells of the pancreatic islets are selectively destroyed. CD8 T cells are regarded as critical players in mediating β cell destruction and as a result, considerable effort has been expended to define CD8 T cell behaviour in this d...
ORGANISM(S): Homo sapiens 
2018-08-03 | E-MTAB-6727 | biostudies-arrayexpress
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