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ProteomicsEnabling phenotypic drug discovery for neurological mitochondrial DNA disorders with patient-derived neural progenitor cells
Mitochondrial DNA (mtDNA) mutations predominantly cause neurological diseases. Searching for therapeutic strategies is hindered by the absence of viable neural model systems due to the challenges of engineering mtDNA. We demonstrate that neural progenitor cells (NPCs), rapidly obtained from human in...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080849 | MassIVE
Genomicsena-DATASET-DKFZ-29-05-2020-15:56:12:496-205 - samples
ALI culture bronchial cells and alveolar lung surgical resection scRNA-Seq
EGAD00001006185 | EGA
2019 novel coronavirus infection 2019-nCoV infection coronavirus disease 2019 COVID-19 SARS-coronavirus 2 SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 
GenomicsSARS‐CoV‐2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells
The SARS‐CoV‐2 pandemic affecting the human respiratory system severely challenges public health and urgently demands for increasing our understanding of COVID‐19 pathogenesis, especially host factors facilitating virus infection and replication. SARS‐CoV‐2 was reported to enter cells via binding to...
EGAS00001004419 | EGA
2019 novel coronavirus infection 2019-nCoV infection coronavirus disease 2019 COVID-19 SARS-coronavirus 2 SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 
GenomicsDAC for patient-derived cell line samples
Data Access Committee EGAC00001000594
EGAC00001000594 | EGA
UnknownClinical outcomes of fractional flow reserve by computed tomographic angiography-guided diagnostic strategies vs. usual care in patients with suspected coronary artery disease: the prospective longitudinal trial of FFR(CT): outcome and resource impacts study.
Not available
S-EPMC4677273 | biostudies-literature
UnknownIntravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data.
Not available
S-EPMC7734592 | biostudies-literature
UnknownCurrent treatment in macrophage activation syndrome worldwide: a systematic literature review to inform the METAPHOR project.
Not available
S-EPMC11701305 | biostudies-literature
UnknownCo-infection and ICU-acquired infection in COIVD-19 ICU patients: a secondary analysis of the UNITE-COVID data set.
Not available
S-EPMC9347163 | biostudies-literature
UnknownEarly mobilisation in critically ill COVID-19 patients: a subanalysis of the ESICM-initiated UNITE-COVID observational study.
Not available
S-EPMC10645963 | biostudies-literature
UnknownClinical and organizational factors associated with mortality during the peak of first COVID-19 wave: the global UNITE-COVID study.
Not available
S-EPMC9123859 | biostudies-literature
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