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GenomicsHeterogeneous immune and tumor clonal evolution patterns in liver cancer
Paired end whole exome sequencing for patient 10, matched normal and tumor
ORGANISM(S): Homo sapiens 
2020-02-01 | E-MTAB-8127 | biostudies-arrayexpress
GenomicsMassive parallel sequencing uncovers actionable FGFR2-PPHLN1 fusion and ARAF mutations in intrahepatic cholangiocarcinoma
Intrahepatic cholangiocarcinoma (iCCA) is a fatal bile duct cancer with dismal prognosis and limited therapeutic options. By performing RNA- and exome sequencing analyses we have discovered a novel fusion event, FGFR2-PPHLN1 (16%), and damaging mutations in the ARAF oncogene (11%). Methods: mRNA and...
ORGANISM(S): Homo sapiens 
2015-01-22 | E-GEOD-63420 | biostudies-arrayexpress
TranscriptomicsProstate Cancer (PRC) training cohort for small RNA characterization
RNA sequencing study on prostate cancer (PRC) cohort for small RNA characterization across biofluids, tissue types and isolation techniques.
ORGANISM(S): Homo sapiens 
2022-06-01 | E-MTAB-8529 | biostudies-arrayexpress
TranscriptomicsHepatocellular Carcinoma (HCC) biomarker discovery cohort for small RNA profiling
Patients with Hepatocellular Carcinoma (HCC) and without HCC used for small read cluster identification and small RNA profiling.
ORGANISM(S): Homo sapiens 
2022-06-01 | E-MTAB-8528 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling of multiregional sampling in hepatocellular carcinoma
The purpose of this experiment is to characterize the intratumor heterogeneity in liver cancer and to study the crosstalk between the immune component of the tumor and the aberrant hepatocites.
ORGANISM(S): Homo sapiens 
2020-01-16 | E-MTAB-5905 | biostudies-arrayexpress
TranscriptomicsTranscriptome signature in early biopsies of stably functioning kidney allografts identify patients at risk for chronic injury
Chronic injury in kidney transplants remains a major cause of graft loss. The aim of this study was to identify a predictive gene set capable of classifying renal grafts at risk for progressive injury due to fibrosis.The Genomics of Chronic Allograft Rejection (GoCAR) study is a prospective, multice...
ORGANISM(S): Homo sapiens 
2016-07-20 | E-GEOD-57387 | biostudies-arrayexpress
TranscriptomicsRNA-seq of the human HCC cell line PLC5 after 72 hours treatment with either MAGEA3 shRNA or Scramble control
To better understand the mechanism by which MAGEA3 contributes to HCC progression, we conducted RNA sequencing in the PLC5 HCC cell line after 72 hours of treatment with scramble or sh8375 in triplicate. RNA-sequencing was conducted on poly-A enriched RNA, 100 bp single reads using an Illumina HiSeq...
ORGANISM(S): Homo sapiens 
2021-05-19 | E-MTAB-8860 | biostudies-arrayexpress
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