Transcriptome signature in early biopsies of stably functioning kidney allografts identify patients at risk for chronic injury

ABSTRACT: Chronic injury in kidney transplants remains a major cause of graft loss. The aim of this study was to identify a predictive gene set capable of classifying renal grafts at risk for progressive injury due to fibrosis.The Genomics of Chronic Allograft Rejection (GoCAR) study is a prospective, multicenter study. Biopsies obtained prospectively 3 months after transplantation from renal allograft recipients (n=159) with stable renal function were analyzed for gene expression by microarray. Genes were sought which correlated with subsequent 12-month Chronic Allograft Damage Index (CADI) but neither CADI in the 3 month biopsy nor other histological or clinical parameters. We identified a set of 13 genes that was independently predictive for the development of fi brosis at 1 year (ie, CADI-12 >=2

ORGANISM(S): Homo sapiens

SUBMITTER: Weijia Zhang 

PROVIDER: E-GEOD-57387 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress