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TranscriptomicsSignaling pathways in skeletal muscle of Amyotrophic Lateral Sclerosis mouse model
Gene expression analyses through cDNA microarray of fifteen gastrocnemius muscles from transgenic and wild-type SOD1G93A mouse model by the ages of 40 and 80 days old were performed. We used a customized cDNA array containing the cDNA platform comprised of 2352 spots, 326 of them orthologous to mous...
ORGANISM(S): Mus musculus 
2014-01-22 | E-GEOD-40328 | biostudies-arrayexpress
TranscriptomicsAn intricate interplay between astrocytes and motor neurons in ALS
Amyotrophic Lateral Sclerosis (ALS) results from the selective and progressive degeneration of motor neurons. Although the underlying disease mechanisms remain unknown, glial cells have been implicated in ALS disease progression. Here we examine the effects of glial cell/motor neuron interactions on...
ORGANISM(S): Mus musculus 
2013-02-11 | E-GEOD-43879 | biostudies-arrayexpress
GenomicsSMN and Symmetric Arginine Dimethylation of RNAP II CTD Control Termination
The C-terminal domain (CTD) of the RNA polymerase II (RNAPII) subunit POLR2A is a platform for modifications specifying the recruitment of factors that regulate transcription, mRNA processing, and chromatin remodeling. Here, we show that a CTD arginine residue (R1810 in human) that is conserved acr...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-73379 | biostudies-arrayexpress
GenomicsGenome-wide landscape of liver X receptor chromatin binding and gene regulation
Gene expression: Identification of primary target genes of liver X receptor (LXR) in an immune-related cellular model (THP-1 cells) to study, in conjunction with LXR binding data from ChIP-seq, the genome-wide mechanisms of transcriptional regulation by LXR. ChIP-Seq: We performed ChIP-seq in macro...
ORGANISM(S): Homo sapiens 
2012-02-02 | E-GEOD-28319 | biostudies-arrayexpress
TranscriptomicsaSyn polyA-RNAseq in PD and unaffected cortical brain samples
We sought to more precisely characterize the different alpha-synuclein (aSyn) 3M-bM-^@M-^YUTR mRNA species in normal and PD human brain. High-throughput, whole-transcriptome sequencing of the 3M-bM-^@M-^YUTR ends of polyadenylated mRNA transcripts (termed pA-RNAseq; see Methods) was performed on a ...
ORGANISM(S): Homo sapiens 
2012-10-04 | E-GEOD-40710 | biostudies-arrayexpress
TranscriptomicsChange of fate comitment in adult neural progenitor cells subjected to chronic inflammation
Neural progenitor cells (NPCs) have regenerative capabilities that are activated during inflammation. By measuring the global transcriptome and performing functional studies, we aimed at elucidating if and how NPCs from the non-germinal niche of the spinal cord differ from germinal niche NPCs, here ...
ORGANISM(S): Rattus norvegicus 
2014-09-09 | E-GEOD-46373 | biostudies-arrayexpress
TranscriptomicsAnalysis of the genome content of Lactococcus garvieae by genomic interspecies microarray hybridization
Background: Lactococcus garvieae is a bacterial pathogen that affects different animal species and human. Despite the widespread distribution and emerging clinical significance of L. garvieae in both veterinary and human medicine, there is almost a complete lack of knowledge about the genetic conte...
ORGANISM(S): Lactococcus garvieae 
2010-03-23 | E-GEOD-19005 | biostudies-arrayexpress
UnknownAssociation of acetaminophen use with perinatal outcomes among pregnant women: a retrospective cohort study with propensity score matching.
Not available
S-EPMC11010302 | biostudies-literature
UnknownModified glomerular filtration rate-estimating equations developed in asiatic population for chinese patients with type 2 diabetes.
Not available
S-EPMC3966408 | biostudies-literature
TranscriptomicsDivergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs
This SuperSeries is composed of the following subset Series: GSE40649: Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs (microarray) GSE40651: Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs (CLIP-Seq) G...
ORGANISM(S): Mus musculus 
2012-09-30 | E-GEOD-40653 | biostudies-arrayexpress
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