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TranscriptomicsSPECtre: a spectral coherence-based classifier of actively translated transcripts from ribosome profiling sequence data
Active protein translation can be assessed and measured using ribosome profiling sequencing strategies. Existing approaches make use of sequence fragment length or frame occupancy to differentiate between active translation and background noise, however they do not consider additional characteristic...
ORGANISM(S): Homo sapiens 
2016-07-01 | E-GEOD-75947 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of Xenopus tRNA isoacceptor families, RNA Polymerase III target genes and selected mRNAs in control and fgf4/wnt8 induced animal cap explants at NF stage 25
Animal poles of 1 to 2-cell stage embryos were injected with a cocktail containing 5pg of Fgf4 and 50pg wnt8 mRNA. Embryos were grown alongside batch controls to NF stage 8/9. Animal cap explants were dissected from the embryos and grown overnight in NAM alongside whole embryo controls as a means of...
ORGANISM(S): Xenopus tropicalis 
2019-09-30 | E-MTAB-7752 | biostudies-arrayexpress
UnknownAlbumin and the fibrinogen-to-albumin ratio: Biomarkers for the acute phase response following total knee arthroplasty.
Not available
S-EPMC7886137 | biostudies-literature
TranscriptomicsMicroarray analysis of Xenopus tRNA isoacceptor families, RNA Polymerase III target genes and selected mRNAs in dorsal embryonic segments of control embryos, or embryos either overexpressing the Polymerase III subunit Polr3G or its paralog Polr3gL at NF stage 25
Embryos were injected at the 1 or 2 cell stage with 2ng of Polr3G or Polr3gL mRNA. Embryos were grown alongside batch controls to NF stage 25 and dorsal embryonic segments were dissected to enrich for myogenic tissue. Through inclusion of selected developmental regulatory mRNAs, we aimed to use this...
ORGANISM(S): Xenopus tropicalis 
2019-09-30 | E-MTAB-7736 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of Xenopus tRNA isoacceptor families, RNA Polymerase III target genes and selected mRNAs in whole control embryos or embryos overexpressing the Polymerase III subunit Polr3G at NF stage 9
Embryos were injected at the 1 or 2 cell stage with 2ng of Polr3G mRNA. Embryos were grown alongside batch controls to NF stage 9 in order to determine immediate changes in transcription of tRNAs at Midblastula Transition. Through inclusion of selected developmental regulatory mRNAs, we aimed to use...
ORGANISM(S): Xenopus tropicalis 
2019-09-30 | E-MTAB-7735 | biostudies-arrayexpress
TranscriptomicsCrebA is a major and direct regulator of secretory pathway gene expression
Abstract: Secretion occurs in all cells, with relatively low levels in most cells and extremely high levels in specialized secretory cells, such as those of the pancreas, salivary and mammary glands. Here, we report that the CrebA/Creb3-like family of bZip transcription factors functions to upregul...
ORGANISM(S): Drosophila melanogaster 
2010-10-18 | E-GEOD-23346 | biostudies-arrayexpress
TranscriptomicsActive Creb3L1 can upregulate secretory pathway genes in HeLa cells
Abstract: Secretion occurs in all cells, with relatively low levels in most cells and extremely high levels in specialized secretory cells, such as those of the pancreas, salivary and mammary glands. Here, we report that the CrebA/Creb3-like family of bZip transcription factors functions to upregul...
ORGANISM(S): Homo sapiens 
2010-10-18 | E-GEOD-23334 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation of mouse and human cell lines and tissues using E2F4 antibodies
Despite being expressed in most tissues, a number of mammalian process-specific transcriptional regulators, such as those involved in cell cycle and immune responses, often have profound tissue-specific phenotypes. The mechanism underlying this effect is poorly understood. We chose to investigate ...
ORGANISM(S): Mus musculus 
2007-07-05 | E-TABM-272 | biostudies-arrayexpress
UnknownThe CrebA/Creb3-like transcription factors are major and direct regulators of secretory capacity
Not available
S-JCBD-201004062 | bioimages
TranscriptomicsMelanoma-derived exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through upregulation of the MET oncoprotein.
Tumor-derived exosomes are emerging as mediators of tumorigenesis with a tissue-specific address and message. We explored the function of melanoma-derived exosomes in formation of primary tumors and metastatic progression in both murine models and patients. Whereas exosomes from highly metastatic me...
ORGANISM(S): Mus musculus 
2012-05-26 | E-GEOD-36584 | biostudies-arrayexpress
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