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TranscriptomicsHigh titers and low fucosylation of early anti-SARS-CoV-2 IgG promote hyper-inflammation by anti-inflammatory macrophages (MIL10)
Patients diagnosed with coronavirus disease 2019 (COVID-19) mostly become critically ill around the time of activation of the adaptive immune response. Here, we provide evidence that antibodies play a role in the worsening of disease at the time of seroconversion. We show that early phase severe acu...
ORGANISM(S): Homo sapiens 
2021-04-30 | E-MTAB-10431 | biostudies-arrayexpress
GenomicsA novel phosphate-starvation response in fission yeast requires the endocytic function of Myosin I (ChIP-seq)
S. pombe Myosin I (MyoI) plays a key role in cytoskeletal functions, in particular it is part of the endocytotic machinery. Here we show a novel role for MyoI in regulating the response to low phosphate stress. Deletion of MyoI led to an increased proliferation in low phosphate media when compared t...
ORGANISM(S): Schizosaccharomyces pombe 
2015-09-15 | E-GEOD-67105 | biostudies-arrayexpress
TranscriptomicsExposure of C. elegans to AOBr-containing surface water samples and to a M. aeruginosa batch culture
Elevated levels of adsorbable organic bromine compounds (AOBr) have been detected in German lakes, and cyanobacteria like Microcystis, which are known for the synthesis of microcystins, are one of the main producers of natural organobromines. However, very little is known about how environmental rea...
ORGANISM(S): Caenorhabditis elegans 
2015-05-12 | E-GEOD-68709 | biostudies-arrayexpress
UnknownMinimal Treatment of Low-Risk, Pediatric Lymphocyte-Predominant Hodgkin Lymphoma: A Report From the Children's Oncology Group.
Not available
S-EPMC4981978 | biostudies-literature
TranscriptomicsTranscription profiling of mouse lipopolysaccharide-induced inflammation in HFE-deficient and wild types
Inflammation influences iron balance in the whole organism. A common clinical manifestation of these changes is the anemia of chronic disease (ACD; also called anemia of inflammation). Inflammation reduces duodenal iron absorption and increases macrophage iron storage, resulting in low serum iron co...
ORGANISM(S): Mus musculus 
2004-03-15 | E-MEXP-95 | biostudies-arrayexpress
TranscriptomicsA novel phosphate-starvation response in fission yeast requires the endocytic function of Myosin I (RNA-seq)
S. pombe Myosin I (MyoI) plays a key role in cytoskeletal functions, in particular it is part of the endocytotic machinery. Here we show a novel role for MyoI in regulating the response to low phosphate stress. Deletion of MyoI led to an increased proliferation in low phosphate media when compared t...
ORGANISM(S): Schizosaccharomyces pombe 
2015-09-15 | E-GEOD-65579 | biostudies-arrayexpress
UnknownMRD4U: A path to development for personalized liquid biopsy for children with central nervous system tumors.
Not available
S-EPMC12374395 | biostudies-literature
TranscriptomicsA human iPSC model of Hutchinson Gilford Progeria Syndrome reveals a possible mesenchymal stem cell defect
Hutchinson Gilford Progeria Syndrome (HGPS) is a rare, sporadic genetic disease caused by mutations in the nuclear lamin A gene. In most cases the mutation creates an efficient donor-splice site that generates an altered transcript encoding a truncated lamin A protein, progerin. In vitro studies ha...
ORGANISM(S): Homo sapiens 
2010-12-23 | E-GEOD-26093 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat fibroblast-like synoviocyte cell cultures treated with TNFa and SB203580
Gene expression affected by TNFa was investigated, then, p38 inhibitor SB203580 was used to investigate p38 signal pathway. Experiment Overall Design: Fibroblast-like synoviocyte culture was treated with TNFa in the presence and absence of SB203580 and compared to the gene expression not treated wi...
ORGANISM(S): Rattus norvegicus 
2008-06-15 | E-GEOD-7826 | biostudies-arrayexpress
TranscriptomicsSelection for improved energy efficiency and drought tolerance in canola results in distinct transcriptome and epigenome changes [RNA-Seq]
Integrated breeding strategies are used to increase both the yield potential and stability of crops. Most of these approaches have a direct genetic basis. The utility of epigenetics in breeding to improve complex traits such as yield and stress tolerance is not clear. A better understanding of th...
ORGANISM(S): Brassica napus 
2015-06-28 | E-GEOD-65572 | biostudies-arrayexpress
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