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MetabolomicsLow-temperature induced neuro-oxidative stress and metabolic reprogramming in the brain of juvenile fourfinger threadfin (Eleutheronema tetradactylum)
This study investigated the effects of low-temperature stress on the brain metabolome of juvenile fourfinger threadfin (Eleutheronema tetradactylum). Using UHPLC-Q-TOF-MS-based untargeted metabolomics, we analyzed brain tissues from fish exposed to 28°C (control) and 18°C for 7 and 14 days. The aim ...
2026-07-22 | MTBLS15103 | MetaboLights
MetabolomicsMetabolomics-Based Analysis of Adaptive Mechanism of Eleutheronema tetradactylum to Low-Temperature Stress

Temperature is a critical environmental factor influencing fish physiology. Eleutheronema tetradactylum is an economically important warm-water species, but its response to long-term cold stress remains unclear. In this study, we exposed juvenile fish to 18 °C for 7 and 14 days and investigated h...

2026-09-08 | MTBLS15459 | MetaboLights
TranscriptomicsExpression profiles of X-ray responsive miRNA in human cells
MicroRNA (miRNA) is a type of non-coding RNA that regulates the expression of its target genes by interacting with the complementary sequence of the target mRNA molecules. Recent evidence has shown that genotoxic stress induces miRNA expression, but the target genes involved and role in cellular res...
ORGANISM(S): Homo sapiens 
2014-03-14 | E-GEOD-30132 | biostudies-arrayexpress
TranscriptomicsLow dose irradiation enhances gene targeting in human pluripotent stem cells
Human pluripotent stem cells (hPSCs) are now being used for both disease modeling and cell therapy. However, efficient homologous recombination (HR) is often crucial to develop isogenic control or reporter lines. Here we show that limited low dose irradiation (LDI) using either γ-ray or X-ray ex...
ORGANISM(S): Homo sapiens 
2016-03-22 | E-GEOD-68328 | biostudies-arrayexpress
TranscriptomicsExpression profiles of X-ray responsive miRNA in human cells [mRNA data]
'MicroRNA (miRNA) is a type of non-coding RNA that regulates the expression of its target genes by interacting with the complementary sequence of the target mRNA molecules. Recent evidence has shown that genotoxic stress induces miRNA expression, but the target genes involved and role in cellular re...
ORGANISM(S): Homo sapiens 
2014-03-14 | E-GEOD-30131 | biostudies-arrayexpress
TranscriptomicsIntegrated array-CGH and expression microarray analyses on medulloblastomas in heterozygous Ptch1 mice, expression
Genomic radiation signature illuminates low-dose effects with sharply reflected transcriptome in Ptch1-deficient medulloblastomas. Cancer risks of low-dose radiation are of great concern especially in relation to rapidly increasing medical exposures; however, their accurate assessments cope with man...
ORGANISM(S): Mus musculus 
2010-07-14 | E-GEOD-19360 | biostudies-arrayexpress
TranscriptomicsIntegrated array-CGH and expression microarray analyses on medulloblastomas in heterozygous Ptch1 mice, aCGH 2
Genomic radiation signature illuminates low-dose effects with sharply reflected transcriptome in Ptch1-deficient medulloblastomas. Cancer risks of low-dose radiation are of great concern especially in relation to rapidly increasing medical exposures; however, their accurate assessments cope with man...
ORGANISM(S): Mus musculus 
2010-07-14 | E-GEOD-19382 | biostudies-arrayexpress
TranscriptomicsIntegrated array-CGH and expression microarray analyses on medulloblastomas in heterozygous Ptch1 mice, aCGH 1
Genomic radiation signature illuminates low-dose effects with sharply reflected transcriptome in Ptch1-deficient medulloblastomas. Cancer risks of low-dose radiation are of great concern especially in relation to rapidly increasing medical exposures; however, their accurate assessments cope with man...
ORGANISM(S): Mus musculus 
2010-07-14 | E-GEOD-19381 | biostudies-arrayexpress
TranscriptomicsLow-level Gamma Ray Exposure to Rice Seedlings in Iitate Village (Fukushima) Activates Self-defense Responses Unraveled by DNA Microarray Analysis
In the summer of 2012, one year after the 3.11 accident at Fukushima Daiichi nuclear power plant following the Great Tohoku Earthquake, a project was initiated to examine the effects of low-level gamma radiation on rice plants. The site of the experiment was the highly contaminated Iitate village in...
ORGANISM(S): Oryza sativa 
2013-12-07 | E-GEOD-53055 | biostudies-arrayexpress
TranscriptomicsGene expression in mouse blood following low dose-rate or acute x-ray exposure
Radiation biodosimetry can play a critical role in the response to a large-scale radiologic emergency, and gene expression profiles have shown promise for providing biodosimetric information. This study was designed to test if gene expression could be used to distinguish between doses received from ...
ORGANISM(S): Mus musculus 
2015-05-14 | E-GEOD-62623 | biostudies-arrayexpress
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