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TranscriptomicsTranscription profiling of mouse embryonic fibroblasts Rb-/- MEF (ME3) and Rb+/+ MEF (MEFA) during adipocyte differentiation
Gene expression of Retinoblastoma deficient mouse embryonic fibroblasts (Rb-/- MEF, ME3) and wildtype mouse embryonic fibroblasts (Rb+/+ MEF,MEFA) during adipocyte differentiation were studied by cDNA microarray analysis. 2-day postconfluent cells (day 0) were treated with a hormonal cocktail includ...
ORGANISM(S): Mus musculus 
2010-01-20 | E-MARS-12 | biostudies-arrayexpress
GenomicsGenome-wide mapping of early replication fragile sites (ERFS)
DNA double strand breaks (DSBs) in B lymphocytes are thought to arise stochastically during replication (S phase) or as a result of targeted DNA damage by activation induced cytidine deaminase (AID) in G1. Here we identify a novel class of recurrent, early replicating and AID independent DNA lesi...
ORGANISM(S): Mus musculus 
2013-02-04 | E-GEOD-43504 | biostudies-arrayexpress
GenomicsDNA binding factors shape the mouse methylome at distal regulatory regions [ChIP-seq].
To gain insights into the interplay between DNA methylation and gene regulation we generated a basepair resolution reference map of the mouse methylome in stem cells and neurons. High genome coverage allowed for a novel quantitative analysis of local methylation states, which identified Low Methylat...
ORGANISM(S): Mus musculus 
2011-12-09 | E-GEOD-30203 | biostudies-arrayexpress
UnknownGenomic classifier identifies men with adverse pathology after radical prostatectomy who benefit from adjuvant radiation therapy.
Not available
S-EPMC4884273 | biostudies-literature
TranscriptomicsTranscriptomic responses in Arabidopsis thaliana to PIPL3 peptide treatment
In order to investigate possible roles of IDL and PIP/PIPL peptides, the transcriptomic response of Arabidopsis seedlings to treatment with PIPL3 peptide was analysed. PIPL3 (At4g37295) was chosen, as no functional data was available for this peptide; furthermore, PIPL3 was expressed in leaf tissue ...
ORGANISM(S): Arabidopsis thaliana 
2015-07-10 | E-GEOD-66201 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of brains from anarchist and wild-type honeybee strains to investigate ovary activation
Effect of genotype (wildtype vs. anarchist) on gene expression in developing (four-day-old) honeybee worker brains. Goal of experiment is to identify genes associated with ovary activation during worker development. These genes are hypothesised to be candidates for the regulation of worker sterility...
ORGANISM(S): Apis mellifera 
2006-10-01 | E-MEXP-699 | biostudies-arrayexpress
TranscriptomicsMycobacterium tuberculosis transcriptional responses to acidic pH and carbon source
The purpose of this study was to examine how Mtb integrates acidic pH and available carbon sources as environmental cues to regulate its metabolism and growth rate. RNA-seq transcriptional profiling of M. tuberculosis growing at acidic or neutral pH, in pyruvate or glycerol, was examined. These stu...
ORGANISM(S): Mycobacterium tuberculosis 
2014-07-07 | E-GEOD-52020 | biostudies-arrayexpress
MetabolomicsHigh-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program
Systemic metabolic alterations associated with increased consumption of saturated fat and obesity are linked with increased risk of prostate cancer progression and mortality, but the molecular underpinnings of this association are poorly understood. Here, we demonstrate in a murine prostate cancer m...
2019-08-22 | MTBLS135 | MetaboLights
TranscriptomicsTranscription profiling of abdomens from anarchist and wild-type honeybee strains to investigate ovary activation
Effect of genotype (wildtype vs. anarchist) on gene expression in developing (four-day-old) honeybee worker abdomens. Goal of experiment is to identify genes associated with ovary activation during worker development. These genes are hypothesised to be candidates for the regulation of worker sterili...
ORGANISM(S): Apis mellifera 
2006-10-01 | E-MEXP-705 | biostudies-arrayexpress
TranscriptomicsReversible and irreversible differentiation of cardiac fibroblasts
Aim: Differentiation of cardiac fibroblasts (Fb) into myofibroblasts (MyoFb) is responsible for connective tissue buildup in myocardial remodeling. We examined reversibility of MyoFb differentiation. Methods and Results: Adult rat cardiac Fb were cultured on a plastic substratum providing mechanical...
ORGANISM(S): Rattus norvegicus 
2014-01-07 | E-GEOD-51824 | biostudies-arrayexpress
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