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MetabolomicsRoot exudate metabolomics of PpPEPC1b-overexpressing rice under phosphate deficiency
Untargeted LC-MS/MS metabolomics of root exudate collection solution from wild-type rice (Oryza sativa L. Zhonghua 11) and three independent overexpression lines (OE8, OE15, OE33) of the elephant grass (Pennisetum purpureum) phosphoenolpyruvate carboxylase gene PpPEPC1b, grown under low phosphate (5...
2026-08-20 | MTBLS15387 | MetaboLights
MetabolomicsMRG15 orchestrates glycolysis and the pentose phosphate pathway to facilitate heart regeneration following myocardial infarction
Metabolic reprogramming is crucial for adult heart regeneration after myocardial infarction (MI). Here, we identify the MORF4-related gene on chromosome 15 (MRG15) as a key orchestrator of cardiomyocyte metabolism to drive cardiomyocyte proliferation. MRG15 expression is upregulated in both hypoxic ...
2026-09-22 | MTBLS15769 | MetaboLights
MetabolomicsMetabolomic Discrimination of Near Isogenic Low and High Phytate Soybean Seeds
Methodologies for untargeted metabolomic profiling using liquid chromatography-mass spectrometry (LC-MS) were developed and applied to lipid-depleted methanolic extracts of soybeans seeds obtained from four near isogenic soybean lines (NILs) that differed in phytate content. The four lines differed ...
2016-02-04 | MTBLS120 | MetaboLights
MetabolomicsOmics and Computational Chemistry Reveal Environmental Residues of Anti-COVID-19 Drug Chloroquine Phosphate Drive Antibiotic Resistance Gene Dissemination
The widespread use of chloroquine phosphate (CQP) during the COVID-19 pandemic has led to its persistent residues in aquatic environments, yet its impact on the horizontal transfer of antibiotic resistance genes (ARGs) remains unknown. Herein, the effects and molecular mechanisms of CQP on plasmid-m...
2026-10-10 | MTBLS15990 | MetaboLights
GenomicsA novel phosphate-starvation response in fission yeast requires the endocytic function of Myosin I (ChIP-seq)
S. pombe Myosin I (MyoI) plays a key role in cytoskeletal functions, in particular it is part of the endocytotic machinery. Here we show a novel role for MyoI in regulating the response to low phosphate stress. Deletion of MyoI led to an increased proliferation in low phosphate media when compared t...
ORGANISM(S): Schizosaccharomyces pombe 
2015-09-15 | E-GEOD-67105 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of wildtype or Hyp (X-linked hypophosphatemic) mouse kidney after feeding control or low phosphate diet to study changes in gene expression in response to low-phosphate diet.
This is a study of the change in gene expression in mouse kidney after feeding control (1.0% P) or low phosphate diet (0.03% P) for 3 or 5 days to normal or Hyp (X-linked hypophosphatemic) mice at 5 weeks of age. The mice were C57BL/6J. Normal wild-type mice, hemizygous Hyp (Hyp/Y) male mice, or h...
ORGANISM(S): Mus musculus 
2007-12-13 | E-GEOD-868 | biostudies-arrayexpress
TranscriptomicsA novel phosphate-starvation response in fission yeast requires the endocytic function of Myosin I (RNA-seq)
S. pombe Myosin I (MyoI) plays a key role in cytoskeletal functions, in particular it is part of the endocytotic machinery. Here we show a novel role for MyoI in regulating the response to low phosphate stress. Deletion of MyoI led to an increased proliferation in low phosphate media when compared t...
ORGANISM(S): Schizosaccharomyces pombe 
2015-09-15 | E-GEOD-65579 | biostudies-arrayexpress
MetabolomicsLow chorionic villous succinate accumulation associates with recurrent spontaneous abortion risk
Dysregulated extravillous trophoblast invasion and proliferation are known to increase the risk of recurrent spontaneous abortion (RSA); however, the underlying mechanism remains unclear. Herein, in our retrospective observational case-control study we show that villous samples from RSA patients, co...
2021-10-06 | MTBLS2148 | MetaboLights
MetabolomicsDynamic utilization of low-molecular-weight organic substrates across a microbial growth rate gradient

AIM: Low-molecular-weight organic substances (LMWOSs) are at the nexus between micro-organisms, plant roots, detritus and the soil mineral matrix. The nominal oxidation state of carbon (NOSC) has been suggested as a potential parameter for modelling microbial uptake rates of LMWO...

2023-08-14 | MTBLS3558 | MetaboLights
GenomicsWhole Genome Bisulfite sequencing of Arabidopsis thaliana High and Low phosphate methylomes
Pi availability is a significant limiting factor for plant growth in both natural and agricultural systems. To cope with such limiting conditions, plants have adapted developmental and biochemical strategies to enhance Pi acquisition and to avoid starvation. A myriad of genes that are involved in th...
ORGANISM(S): Arabidopsis thaliana 
2015-12-31 | E-GEOD-72770 | biostudies-arrayexpress
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