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TranscriptomicsBRAF Mutation Is Rare in Advanced-Stage Low-Grade Ovarian Serous Carcinomas
Low-grade ovarian serous carcinomas are believed to arise via an adenoma-serous borderline tumor-serous carcinoma sequence. In this study, we found that advanced-stage, low-grade ovarian serous carcinomas both with and without adjacent serous borderline tumor shared similar regions of loss of hetero...
ORGANISM(S): Homo sapiens 
2011-03-04 | E-GEOD-27659 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human LMP ovarian tumors and low-grade ovarian carcinomas to identify genes which dffer from high-grade ovarian carcinomas - PAX2: a potential biomarker for low malignant potential ovarian tumors and low-grade serous ovarian carcinomas
Objective: Ovarian tumors of low-malignant potential (LMP) and low-grade serous ovarian carcinomas are thought to represent different stages on a tumorigenic continuum and to develop along pathways distinct from that of high-grade serous ovarian carcinoma. Past studies have utilized gene expression...
ORGANISM(S): Homo sapiens 
2009-06-08 | E-GEOD-14001 | biostudies-arrayexpress
TranscriptomicsGeneration of low passage high grade serous ovarian cancer cell lines from primary tumors
High grade serous ovarian cancers (HGSC) are deadly malignancies that relapse despite carboplatin chemotherapy. Many commercially ovarian cancer cell lines are not good models for HGSC. Here we demonstrate that 3 low passage cell lines derived from HGSC have similar transcriptomes to their parental...
ORGANISM(S): Homo sapiens 
2015-08-01 | E-GEOD-70073 | biostudies-arrayexpress
ProteomicsChanges in the tumor microenvironment mark transition from serous borderline tumor to low grade serous carcinoma
Low grade serous ovarian cancer (LGSC) is a rare subtype of ovarian cancer, characterized by a slow growth rate, resistance to current treatment regimens, multiple recurrences and poor survival. LGSC arise from serous borderline tumor (SBT), however the mechanism of transformation is poorly understo...
ORGANISM(S): Homo sapiens (Human) 
2024-08-15 | PXD046360 | Pride
Tmt Ovarian cancer Serous borderline tumor 
TranscriptomicsImmune-activation as a therapeutic direction for patients with high-risk ovarian cancer based on gene expression signature (2)
Advanced-stage ovarian cancer is one of the most lethal gynecologic malignancies. To improve prognosis of patients with ovarian cancers, a predictive biomarkers leading to personalized treatments are required. In this large-scale cross-platform study of six microarray datasets consisting of 1054 ova...
ORGANISM(S): Homo sapiens 
2012-03-01 | E-GEOD-32063 | biostudies-arrayexpress
GenomicsLncRNA and mRNA expression profiles in High-grade serous ovarian cancer, Low-grade serous ovarian cancer and Normal fallopian tube
LncRNA and mRNA expression profiles in High-grade serous ovarian cancer, Low-grade serous ovarian cancer and Normal fallopian tube
PRJNA560410 | ENA
TranscriptomicsImmune-activation as a therapeutic direction for patients with high-risk ovarian cancer based on gene expression signature (1)
The Japanese Serous Ovarian Cancer Study Group Advanced-stage ovarian cancer is one of the most lethal gynecologic malignancies. To improve prognosis of patients with ovarian cancers, a predictive biomarkers leading to personalized treatments are required. In this large-scale cross-platform study of...
ORGANISM(S): Homo sapiens 
2012-03-01 | E-GEOD-32062 | biostudies-arrayexpress
TranscriptomicsMevalonate pathway antagonist inhibits proliferation of serous tubal intraepithelial carcinoma and ovarian carcinoma in mouse models.
Statins are among the most frequently prescribed drugs because of their efficacy and low toxicity in treating hypercholesterolemia. Recently, statins have been reported to inhibit the proliferative activity of cancer cells, especially those with *TP53* mutations. Since *TP53* mutations occur in ...
ORGANISM(S): Homo sapiens 
2015-11-04 | E-GEOD-68986 | biostudies-arrayexpress
ProteomicsQuantitative proteomics identifies conserved proteins and altered regulation of mucin-16 in low grade serous ovarian cancers.
Low-grade serous ovarian carcinoma (LGSOC) is a rare and largely chemoresistant subtype of epithelial ovarian cancer. Unlike treatment for high-grade serous ovarian cancer (HGSOC), management options for LGSOC patients are limited, in part, due to a lack of deep molecular characterization of this di...
ORGANISM(S): Homo sapiens (Human) 
2025-09-30 | PXD050642 | Pride
Low-grade serous ovarian cancer High-grade serous ovarian cancer Lgsoc Fallopian tube Hgsoc Quantitative proteomics 
TranscriptomicsGene expression analysis of human serious ovarian tumors and fimbria control
The cell of origin of serious ovarian cancer is unknown. To create a mouse model for this lethal cancer and identify early cancer biomarkers, we conditionally deleted both Dicer (essential for microRNA biosynthesis) and Pten (a negative regulator of the PI3K pathway) in the female reproductive tract...
ORGANISM(S): Homo sapiens 
2012-02-16 | E-GEOD-28721 | biostudies-arrayexpress
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