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ProteomicsSurface proteome profiling of p53-restorable murine liver cancer cells
Characterization of the surface proteome changes between proliferating and senescent liver cancer cells induced by p53 restoration.
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD034465 | Pride
Surface proteome P53 restoration Liver cancer Senescence 
TranscriptomicsA rapid and scalable system for studying gene function in mice using conditional RNA interference
Four libraries were analyzed to assess the level and effects of inducing the ectopic expression of a luciferase targeting miRNA in mouse embryonic fibroblasts (MEFs). Here, we find low level, leaky expression in the absence of ROSA-rtTA and doxycyclin. When expression is effectively induced, the Luc...
ORGANISM(S): Mus musculus 
2010-12-01 | E-GEOD-19476 | biostudies-arrayexpress
TranscriptomicsExpression data from either growing IMR90 human fibroblasts or senescent IMR90 cells with Ras expression and indicated hairpins
Oncogene-induced senescence is an anti-proliferative stress response program that acts as a fail-safe mechanism to limit oncogenic transformation and is regulated by the retinoblastoma protein (RB) and p53 tumor suppressor pathways. We identify the atypical E2F family member E2F7 as the only E2F t...
ORGANISM(S): Homo sapiens 
2012-08-25 | E-GEOD-40349 | biostudies-arrayexpress
Proteomics,MultiomicsIdentification SETD1A-binding proteins by Co-IP MS
The dataset contains the gelLC MS analysis of immunoprecipitated complex from full-lenght and truncated SETD1A. The protein was ectopically expressed and the binders immunoprecipitated in cell transduced with the empty vector were analyzed as control.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-08-01 | MSV000080012 | MassIVE
GenomicsH3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence (ChIP-seq)
Cellular senescence is a tumor-suppressive program that involves chromatin reorganization and specific changes in gene expression that trigger an irreversible cell-cycle arrest. We combined quantitative mass spectrometry and ChIP deep-sequencing to identify changes in histone modification occurring ...
ORGANISM(S): Homo sapiens 
2013-01-31 | E-GEOD-43921 | biostudies-arrayexpress
TranscriptomicsH3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence (expression)
Cellular senescence is a tumor-suppressive program that involves chromatin reorganization and specific changes in gene expression that trigger an irreversible cell-cycle arrest. We have examined the effect of suppressing the histone demethylases Jarid1a and Jarid1b on the senescence-associated gene ...
ORGANISM(S): Homo sapiens 
2013-01-31 | E-GEOD-43920 | biostudies-arrayexpress
TranscriptomicsChromosomal deletions linked to p53 loss of heterozygosity promote cancer through p53-independent mechanisms
The purpose of current study is to identify the differentiated gene expression associated with mouse 11B3 deletion, syntenic to human chromosome 17p13.1. We compared four different mouse acute myeloid leukemia cells, freshly isolated from mouse bone marrows with either 11B3fl/p53fl;shNf1;shMll3;Vav1...
ORGANISM(S): Mus musculus 
2016-04-04 | E-GEOD-69654 | biostudies-arrayexpress
GenomicsGenome wide maps of E2F7 binding in IMR90 cells
Oncogene-induced senescence is an anti-proliferative stress response program that acts as a fail-safe mechanism to limit oncogenic transformation and is regulated by the retinoblastoma protein (RB) and p53 tumor suppressor pathways. We identify the atypical E2F family member E2F7 as the only E2F t...
ORGANISM(S): Homo sapiens 
2012-08-25 | E-GEOD-40343 | biostudies-arrayexpress
TranscriptomicsAffymetrix SNP 6.0 profiles of 10 Human B-NHL lines
B-cell Non Hodgkin Lymphoma are a heterogenous group chracterized by a variety of genetic changes, including translocations, deletions and amplifications. Here we analyzed 10 B-NHL lines by Affymetrix SNP 6.0 to detect copy number changes. Specifically, we aim to identify cell lines suitable for te...
ORGANISM(S): Homo sapiens 
2012-04-02 | E-GEOD-36967 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression in lymphoma lines
MicroRNAs from lymphoma and leukemia cell lines with or without the 13q31 amplicon were quantitated using a custom microarray platform. 5ug total RNA from each line was labeled with cy3 and hybridized to a microarray that contains probes to 238 mouse and human mature microRNAs. Four data sets per ...
ORGANISM(S): Homo sapiens 
2010-06-10 | E-GEOD-2399 | biostudies-arrayexpress
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