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TranscriptomicsRegion-specific gene expression profiling of early mouse mandible uncovered SATB2 as a key molecule for teeth patterning
Mammalian dentition exhibits distinct heterodonty, with more simple teeth located in the anterior area of the jaw and more complex teeth situated posteriorly. While some region-specific differences in signaling have been described previously, here we performed gene expression profiling of anterior a...
ORGANISM(S): Mus musculus 
2024-10-31 | E-MTAB-13604 | biostudies-arrayexpress
GenomicsHighly efficient genomic enrichment of human exonic sequences through short-fragment libraries
Microarray-based enrichment of selected genomic loci is a powerful method for genome complexity reduction. Since the vast majority of exons in vertebrate genomes are smaller than 150 nt, we have explored the use of short fragment libraries (85-110bp) to achieve higher enrichment specificity by reduc...
ORGANISM(S): Homo sapiens 
2010-02-01 | E-GEOD-18542 | biostudies-arrayexpress
TranscriptomicsTemporal response of DCs to LPS stimulation: 4sU_sequencing
Regulation of RNA levels is critical for the response to external stimuli and determined through the interplay between RNA production, processing and degradation. Despite the centrality of these processes, most global studies of RNA regulation do not distinguish their separate contributions and rela...
ORGANISM(S): Mus musculus 
2011-04-24 | E-GEOD-25432 | biostudies-arrayexpress
TranscriptomicsMicroglia treatment with C6 glioma-conditioned medium or with LPS
Several independent microglia preparations performed on different days were plated onto wells of 24-well plates, and either left untreated (control), treated with the C6 glioma-conditioned medium, or treated with LPS.
For each culture condition, a number of RNA samples were prepared, with each sa...
ORGANISM(S): Rattus norvegicus 
2012-12-14 | E-MEXP-2466 | biostudies-arrayexpress
MetabolomicsMultiomics of synaptic junctions reveals altered lipid metabolism and signaling following environmental enrichment
Membrane lipids and their metabolism have key functions in neurotransmission. Here we provide a quantitative lipid inventory of mouse and rat synaptic junctions. To this end, we developed a multiomics extraction and analysis workflow to probe the interplay of proteins and lipids in synaptic signal t...
2021-09-27 | MTBLS1531 | MetaboLights
TranscriptomicsGlobal gene expression analysis of heterotypic interactions between cancer cells and osteoblasts in vitro
Bone is the most common site of breast cancer metastasis, and this type of metastasis is a main cause of morbidity. Because breast cancer is a heterogeneous disease, the interactions between the cancer cells and the skeletal host cells, such as osteoblasts, might be diverse. Thus far, these tumor-os...
ORGANISM(S): Homo sapiens 
2012-01-06 | E-GEOD-29036 | biostudies-arrayexpress
TranscriptomicsNormal human osteoblasts and MCF7 mono and coculture
As a model for investigating changes in gene expression in response to epithelial-osteoblast interactions in bone metastases of breast carcinomas, cells that represented malignant epithelial cell compartments (MCF7) and cells that represented skeletal compartments (Normal Human (NH) Osteoblasts) wer...
ORGANISM(S): Homo sapiens 
2012-01-06 | E-GEOD-29032 | biostudies-arrayexpress
TranscriptomicsNormal human osteoblasts and MDA-MB-231 mono and coculture
As a model for investigating changes in gene expression in response to epithelial-osteoblast interactions in bone metastases of breast carcinomas, cells that represented malignant epithelial cell compartments (MDA-MB-231) and cells that represented skeletal compartments (Normal Human (NH) Osteoblast...
ORGANISM(S): Homo sapiens 
2012-01-06 | E-GEOD-29033 | biostudies-arrayexpress
TranscriptomicsNormal human osteoblasts and SKBR3 mono and coculture
As a model for investigating changes in gene expression in response to epithelial-osteoblast interactions in bone metastases of breast carcinomas, cells that represented malignant epithelial cell compartments (SKBR3) and cells that represented skeletal compartments (Normal Human (NH) Osteoblasts) we...
ORGANISM(S): Homo sapiens 
2012-01-06 | E-GEOD-29034 | biostudies-arrayexpress
TranscriptomicsNormal human osteoblasts and T47D mono and coculture
As a model for investigating changes in gene expression in response to epithelial-osteoblast interactions in bone metastases of breast carcinomas, cells that represented malignant epithelial cell compartments (T47D) and cells that represented skeletal compartments (Normal Human (NH) Osteoblasts) wer...
ORGANISM(S): Homo sapiens 
2012-01-06 | E-GEOD-29035 | biostudies-arrayexpress
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