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TranscriptomicsLOXL2 dependent genes in RA induced mES differentiation
Our results indicate that oxidation of TAF10 by LOXL2 induces its release from its promoters, leading to a block in TFIID-dependent gene transcription. Since TFIID complex is crucial for the expression of Nanog, Klf4, Sox2 and Oct4 and for maintaining the pluripotent state of embryonic stem cells, T...
ORGANISM(S): Mus musculus 
2015-12-21 | E-GEOD-65675 | biostudies-arrayexpress
ProteomicsProteomic profiling of human prostate cancer-associated fibroblasts identifies LOXL2 promotes tumour migration in the extracellular matrix
In prostate cancer (PC), cancer-associated fibroblasts (CAFs) exhibit contrasting biological properties to non-malignant prostate fibroblasts (NPFs) and promote tumorigenesis. Resolving intercellular signaling pathways between CAFs and prostate tumor epithelium may offer novel opportunities for rese...
ORGANISM(S): Homo sapiens (Human) 
2019-05-24 | PXD010611 | Pride
Phosphoproteome Fibroblast Loxl2 Prostate cancer 
GenomicsEndothelial gene expression analysis after silencing LOXL2 using siRNAs
Endothelial gene expression analysis after silencing LOXL2 using siRNAs
PRJNA418857 | ENA
GenomicsGene expression analysis following depletion of LOXL2 in esophgeal cancer cells
Gene expression analysis following depletion of LOXL2 in esophgeal cancer cells
PRJNA559146 | ENA
GenomicsLOXL2 protects temporomandibular joint from mitochondrial dysfunction, apoptosis and osteoarthritis like progression
LOXL2 protects temporomandibular joint from mitochondrial dysfunction, apoptosis and osteoarthritis like progression
PRJNA1159874 | ENA
GenomicsLOXL2 identifies inflammation-associated myofibroblasts predicting kidney allograft dysfunction and fibrosis
LOXL2 identifies inflammation-associated myofibroblasts predicting kidney allograft dysfunction and fibrosis
PRJNA1163392 | ENA
TranscriptomicsLysyl oxidase-like 2 (LOXL2) a new regulator of cell polarity required for metastatic dissemination of basal-like breast carcinomas
Basal-like breast carcinoma is characterized by the expression of basal/myoepithelial markers, undifferentiated phenotype, highly aggressive behaviour and a frequent triple negative status (ESR-, PR-, Her2neu-). We have previously shown that epithelial-mesenchymal transition (EMT) occurs in basal-li...
ORGANISM(S): Homo sapiens 
2011-10-20 | E-GEOD-29581 | biostudies-arrayexpress
GenomicsLoss of LOXL2 promotes uterine hypertrophy and tumor progression
Loss of LOXL2 promotes uterine hypertrophy and tumor progression
PRJNA882816 | ENA
GenomicsLOXL2 protects temporomandibular joint from mitochondrial dysfunction, apoptosis and osteoarthritis like progression [RNA-Seq]
LOXL2 protects temporomandibular joint from mitochondrial dysfunction, apoptosis and osteoarthritis like progression [RNA-Seq]
PRJNA1160859 | ENA
TranscriptomicsA novel Lysyl oxidase like 2 alternative splicing LOXL2 â–³e13 in esophageal squamous carcinoma cells
A novel alternative splicing isoform of LOXL2 â–³e13 was expressed ubiquitously in all cell lines and ESCC tissues. In contrast to the impaired deamination enzymatic activity compared with full length LOXL2, LOXL2 â–³e13 showed an enhanced ability to promote cell mobility and invasiveness in ESCC ce...
ORGANISM(S): Homo sapiens 
2016-07-03 | E-GEOD-53676 | biostudies-arrayexpress
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