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UnknownNear-tetraploid cancer cells show chromosome instability triggered by replication stress and exhibit enhanced invasiveness.
Not available
S-EPMC5998968 | biostudies-literature
OtherIdentification of a stable gene signature of tolerance to renal allograft by meta-analysis.
This study corresponds to a re-analysis and meta-analysis of the five transcriptomic studies related to spontaneous tolerance to renal allograft in human. It examines the transcriptome of peripheral blood samples from six distinct clinical groups: healthy volunteers (HV); tolerant patients (TOL); st...
ORGANISM(S): Homo sapiens 
2015-10-06 | GSE49198 | GEO
UnknownDo Cohabitants Reliably Complete Questionnaires for Patients in a Terminal Cancer Stage when Assessing Quality of Life, Pain, Depression, and Anxiety?
Not available
S-EPMC8083839 | biostudies-literature
TranscriptomicsTranscriptomic survey of lymph node-positive vs. - negative ductal breast cancer
Lymph node involvement is a major prognostic variable in breast cancer. Whether the molecular mechanisms that drive breast cancer cells to colonize lymph nodes are shared with their capacity to form distant metastases is yet to be established. In a transcriptomic survey aimed at identifying molecula...
ORGANISM(S): Homo sapiens 
2013-03-05 | E-GEOD-44408 | biostudies-arrayexpress
UnknownAssociation between missense variants of uncertain significance in the CHEK2 gene and hereditary breast cancer: a cosegregation and bioinformatics analysis.
Not available
S-EPMC10927753 | biostudies-literature
TranscriptomicsGene expression profiling and secretome analysis differentiate Adult-Derived Human Liver Stem/progenitor Cells and human hepatic stellate cells
Adult-derived human liver stem/progenitor cells (ADHLSC) are obtained after primary culture of the liver parenchymal fraction. The cells are of fibroblastic morphology and exhibit a hepato-mesenchymal phenotype. Hepatic stellate cells (HSC) derived from the liver non-parenchymal fraction present a c...
ORGANISM(S): Homo sapiens 
2015-05-11 | E-GEOD-49995 | biostudies-arrayexpress
TranscriptomicsGenome-wide methylation profiling of multiple sporadic colorectal cancer
Background an Aim: Epigenetics are thought to play a major role in the carcinogenesis of patients that develop multiple colorectal cancers (CRC) in the non-hereditary setting. Previous studies have suggested concordant DNA hypermethylation between tumor pairs. However, only a few methylation markers...
ORGANISM(S): Homo sapiens 
2014-09-01 | E-GEOD-52573 | biostudies-arrayexpress
TranscriptomicsTranscriptome Analysis Identifies Fn14, a TNF Superfamily Receptor Member, as a Therapeutic Target in Alcoholic Hepatitis
Alcoholic hepatitis (AH) is the most severe form of alcoholic liver disease and occurs in patients with excessive alcohol intake It is characterized by marked hepatocellular damage, steatosis and pericellular fibrosis. Patients with severe AH have a poor short-term prognosis. Unfortunately, current ...
ORGANISM(S): Homo sapiens 
2012-06-14 | E-GEOD-28619 | biostudies-arrayexpress
TranscriptomicsTransportome profiling identifies profound alterations in Crohn’s disease partially restored by commensal bacteria
In the present study, the transcriptional analysis of CD biopsies reveals profound alterations in the ileum transportome profile. More than 60 SLC transporters showed different expression pattern compared with the healthy donors, being mostly decreased. Changes were confirmed in almost all the eight...
ORGANISM(S): Homo sapiens 
2016-03-29 | E-GEOD-68570 | biostudies-arrayexpress
TranscriptomicsMOLECULAR CHARACTERIZATION OF LIVER ALLOGRAFTS FROM OPERATIONALLY TOLERANT TRANSPLANT RECIPIENTS (Affymetrix)
In clinical organ transplantation complete cessation of immunosuppressive therapy can be successfully accomplished in selected recipients providing a proof-of-principle that allograft tolerance is attainable in humans. The intra-graft molecular pathways associated with human allograft tolerance, how...
ORGANISM(S): Homo sapiens 
2012-01-09 | E-GEOD-26622 | biostudies-arrayexpress
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