Lpa - OmicsDI

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CHEBI ID

CHEBI:64563 (5)
CHEBI:64576 (3)
CHEBI:64549 (3)
CHEBI:64561 (3)
CHEBI:70744 (3)
CHEBI:27266 (3)
CHEBI:16196 (3)
CHEBI:72737 (3)
CHEBI:17596 (3)
CHEBI:17351 (3)
CHEBI:141510 (2)
CHEBI:28934 (2)
CHEBI:66865 (2)
CHEBI:141514 (2)
CHEBI:141511 (2)
CHEBI:132744 (2)
CHEBI:66864 (2)
CHEBI:28374 (2)
CHEBI:89417 (2)
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CHEBI:16933 (2)
CHEBI:34159 (2)
CHEBI:32368 (2)
CHEBI:84818 (2)
CHEBI:45919 (2)
CHEBI:9481 (2)
CHEBI:27562 (2)
CHEBI:16795 (2)
CHEBI:35465 (2)

Metabolite Name

PA(40:6) (2)
LPI 18:0 (2)
PS(44:3) (2)
PS(42:8) (2)
PS(42:6) (2)
PS(42:5) (2)
PS(42:4) (2)
PS(42:2) (2)
PS(42:1) (2)
PS(40:8) (2)
PS(40:5) (2)
PS(40:3) (2)
PS(40:2) (2)
PS(40:1) (2)
PS(39:6) (2)
PS(38:5) (2)
PS(38:3) (2)
PS(38:1) (2)
PS(36:3) (2)
PS(34:1) (2)
FA(22:6) (2)
FA(20:4) (2)
FA(16:0) (2)
PS(36:2) (2)
PS(38:4) (2)
PS(38:6) (2)
PS(40:6) (2)
PS(40:7) (2)
PS(40:4) (2)
LPC(20:3) (2)

First Public Date

2024 (22)
2014 (13)
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Classification

bacteria (3)

Study type

Transcription profiling by array (38)
RNA-seq of coding RNA (17)
ChIP-seq (2)
Human - High-throughput sequencing (1)
Animal - High-throughput sequencing (1)
Cell line - High-throughput sequencing (1)
Transcription profiling by tiling array (1)
Comparative genomic hybridization by array (1)
Other (1)
RNA-seq of coding RNA from single cells (1)

Release Date

2022 (220)
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2023 (192)
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2007 (8)
2004 (6)
2005 (5)
2003 (2)
2002 (2)
1999 (2)
1998 (1)
1997 (1)
1996 (1)

Lab affiliation

Michigan State University (2)
Professor, Unversity of British Columbia (2)
Biomedical research centre University of British Columbia (1)
Brigham and Women's Hospital and Harvard Medical School (1)
CMMB, University of South Florida (1)
CRUK Beatson Institute, Switchback Road, Glasgow G61 1BD, UK. (1)
Department of Chemistry, Michigan State University (1)
Department of Chemistry, Michigan State University, 578 S Shaw Lane, East Lansing, MI 48824, USA (1)
Department of Chemistry, Michigan State University, 578 S Shaw Lane, East Lansing, MI 48824, United States (1)
Department of Chemistry, Michigan State University, East Lansing, MI 48824 (1)
Department of Chemistry, Michigan State University, East Lansing, Michigan 48824, United States (1)
Melbourne Veterinary School, Faculty of Science, The University of Melbourne, Parkville, Victoria, Australia (1)
National Heart and Lung Institute, Imperial College London, United Kingdom (1)
No. 169 West Changle Road, Xi’an, Shaanxi, 710032, China. (1)
Professor, University of British Columbia (1)
Team Lead in Proteomics Head of the Proteomics Research Translational Technology Platform UCL Cancer Institute, Paul O’Gorman Building 72 Huntley Street, London, WC1E 6DD, UK (1)
University of Notre Dame (1)

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Inhibition of stress resilience and adult hippocampal neurogenesis by platelet-derived LPA16:0 in anxiety

Anxiety is an aggravating comorbidity of many psychiatric disorders that is often underdiagnosed and undertreated, and little is known on the mechanisms underlying its regulation. Here, we find that serum LPA16:0 abundance increases with trait anxiety in both humans and mice; while high LPA16:0 l...

2026-02-05 | MTBLS13589 | MetaboLights

Transcriptomic analysis of human breast and prostate cancer cell lines on lysophosphatidic acid (LPA) stimulation

LPA is a natural bioactive lipid with growth factor-like functions due to activation of series of six G protein-coupled receptors (LPA1-6). In this study we determine the LPA induced early-gene expression profile in three unrelated human cancer cell lines (MDA-MB-231, MCF7, PC3) with an objective to...

ORGANISM(S): Homo sapiens

2014-05-16 | E-GEOD-56265 | biostudies-arrayexpress

Influence of lysophosphatidic acid (LPA) and LPA together with interferon tau (IFNt) on transcriptional profiling of bovine endometrial cells.

The endometrium plays a crucial role in the reproductive organs in the aspect of embryo-maternal communication and pregnancy. This study investigated transcriptome profiles of endometrial cells stimulated with PBS, LPA and LPA in combination with IFNt. LPA, one of the signaling molecule, is locally ...

ORGANISM(S): Bos taurus

2014-01-10 | E-GEOD-53457 | biostudies-arrayexpress

Human gingival fibroblasts: control vs. lysophosphatidic acid (LPA 18:1)-treated

Transcriptional profiling of pass 2 primary human gingival fibroblasts (GF) comparing control untreated GF with GF treated with LPA 18:1 for 2h or 8h. The goal of this study was to determine the effects of LPA 18:1 on global GF gene expression. Three-condition experiment, GF vs. LPA-treated (2h, 8h)...

ORGANISM(S): Homo sapiens

2014-05-12 | E-GEOD-57496 | biostudies-arrayexpress

Identification of phosphorylation sites regulated by lysophosphatidic acid (LPA) in OCMI91s ovarian cancer cells

Elevated levels of lysophosphatidic acid (LPA) species accumulate in the ascites of ovarian high grade serous cancer (HGSC) and are associated with a short relapse-free survival. LPA is known to support the metastatic spread of cancer cells by activating a multitude of signaling pathways through G-p...

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

2023-01-25 | MSV000091146 | MassIVE

Identification of phosphorylation sites regulated by lysophosphatidic acid (LPA) in OVCAR8 ovarian cancer cells

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

2023-01-26 | MSV000091158 | MassIVE

LPA vs Silica

Metagenomic comparison of LPA and Silica nucleic acid extracts

PRJEB45999 | ENA

Autotaxin and its product lysophosphatidic acid suppress brown adipose differentiation and promote diet-induced obesity in mice

Brown adipose tissue (BAT) is a thermogenic organ that dissipates stored energy as heat to maintain body temperature in infants and small mammals. This process may also provide protection from development of diet-induced obesity. We found that the bioactive lipid mediator lysophosphatidic acid (LP...

ORGANISM(S): Mus musculus

2011-06-01 | E-GEOD-26442 | biostudies-arrayexpress

Chemotaxis in pancreatic ductal adenocarcinoma metastasis: An unexpected role of N-WASP in response of cells to self-generated gradients and LPA receptor trafficking

Pancreatic ductal adenocarcinoma is one of the most invasive and metastatic cancers and has a dismal 5-year survival rate. Here we show that N-WASP is required for the metastatic process, with roles in both chemotaxis, steering cells out of primary tumours, and matrix remodelling, allowing them to ...

ORGANISM(S): Mus musculus (Mouse)

2020-03-06 | PXD014506 | Pride

Transcription profiling of mouse embryonic fibroblast-TBX2 cells treated with LPA or EGF

EXPERIMENT 3: LPA compared to EGF response; LPA concentration 5uM; EGF concentration 50ng/ml

ORGANISM(S): Mus musculus

2009-02-14 | E-NCMF-18 | biostudies-arrayexpress

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