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ProteomicsThanatin Targets the Inter-Membrane Protein Complex Required for Lipopolysaccharide Transport in Escherichia coli
With the increasing resistance of many Gram-negative bacteria to existing classes of antibiotics, identifying new paradigms in antimicrobial discovery is an important research priority. Of special interest here are the proteins required for the biogenesis of the symmetric Gram-negative bacterial out...
ORGANISM(S): Escherichia Coli (ncbitaxon:562) 
2020-02-04 | MSV000084897 | MassIVE
UnknownThe Escherichia coli Lpt transenvelope protein complex for lipopolysaccharide export is assembled via conserved structurally homologous domains.
Not available
S-EPMC3571315 | biostudies-literature
Proteomics• Optimal Functioning of the Lipopolysaccharide Transport Bridge Depends on a Ternary Complex Between the Lipocalin YedD and the LptDE Translocon
The outer membrane is an efficient permeability barrier that protects Gram-negative bacteria against external assaults including many antibiotics. The unique permeability features of the outer membrane are due to the presence of lipopolysaccharide (LPS) molecules in its outer leaflet. LPS localizati...
ORGANISM(S): Escherichia coli 
2025-07-09 | PXD059551 | Pride
Lps Bacteria Lipocalin Outer membrane Translocon 
UnknownInteraction of lipopolysaccharides at intermolecular sites of the periplasmic Lpt transport assembly.
Not available
S-EPMC5575297 | biostudies-literature
ProteomicsThanatin Targets the Inter-Membrane Protein Complex Required for Lipopolysaccharide Transport in Escherichia coli
With the increasing resistance of many Gram-negative bacteria to existing classes of antibiotics, identifying new paradigms in antimicrobial discovery is an important research priority. Of special interest here are the proteins required for the biogenesis of the symmetric Gram-negative bacterial out...
ORGANISM(S): Escherichia coli 
2019-01-23 | PXD010988 | Pride
Photoaffinity labeling Thermo q-exactive plus Macrocyclic peptidomimetic antibiotics Interaction mapping Lpt complex Photo crosslinking Gram-negative eskape pathogens Molecular mode of action E.coli Dda Ompta (outer membrane-targeting antibiotics) Lc-ms/ms 
UnknownSurface lipoprotein sorting by crosstalk between Lpt and Lol pathways in gram-negative bacteria.
Not available
S-EPMC12065857 | biostudies-literature
GenomicsEnhancer-associated H3K4 mono-methylation by Drosophila Trithorax-related, the Drosophila homolog of Mll3/Mll4
Mono-methylation of histone H3 on lysine 4 (H3K4me1) and acetylation of histone H3 on lysine 27 (H3K27ac) are histone modifications that are highly enriched over the body of actively transcribed genes and enhancers. Although in yeast all H3K4 methylation patterns including H3K4me1 are implemented by...
ORGANISM(S): Mus musculus 
2012-12-01 | E-GEOD-41440 | biostudies-arrayexpress
UnknownProteins required for lipopolysaccharide assembly in Escherichia coli form a transenvelope complex.
Not available
S-EPMC2880507 | biostudies-literature
GenomicsGenome-wide binding of Cmi in Drosophila
Cmi (also known as Lpt) is the PHD finger domain-containing subunit of the Drosophila MLR COMPASS (Cmi-Trr) complex. ChIP-seq analysis of Cmi at different stages of Drosophila development suggests dynamic genome localization of the Cmi/MLR complex on enhancers and promoters during Drosophila develop...
ORGANISM(S): Drosophila melanogaster 
2020-04-20 | GSE143747 | GEO
UnknownThanatin Impairs Lipopolysaccharide Transport Complex Assembly by Targeting LptC-LptA Interaction and Decreasing LptA Stability.
Not available
S-EPMC7237710 | biostudies-literature
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