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GenomicsLRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function [ChIP-Seq]
We have determined the cistrome and transcriptome for the nuclear receptor liver receptor homolog-1 (LRH-1) in the exocrine pancreas. Chromatin immunoprecipitation (ChIP)-seq and RNA-seq analyses reveal that LRH-1 directly induces expression of genes encoding digestive enzymes and secretory and mit...
ORGANISM(S): Mus musculus 
2011-12-09 | E-GEOD-34295 | biostudies-arrayexpress
GenomicsLRH-1 governs vital transcriptional programs in endocrine sensitive and resistant breast cancer cells: LRH-1 ChIP-seq
Tumor characteristics are decisive in the determination of treatment strategy for breast cancer patients. Patients with estrogen receptor a(ERa)-positive breast cancer can benefit from long-term hormonal treatment. Nonetheless, the majority of patients will develop resistance to these therapies. Her...
ORGANISM(S): Homo sapiens 
2014-02-27 | E-GEOD-47027 | biostudies-arrayexpress
TranscriptomicsNuclear receptor LRH-1/NR5A2 is required and targetable for liver endoplasmic reticulum stress resolution.
Chronic endoplasmic reticulum (ER) stress results in toxicity that contributes to multiple human disorders. We report a stress resolution pathway initiated by the nuclear receptor LRH-1 that is independent of known unfolded protein response (UPR) pathways. Like mice lacking primary UPR components, h...
ORGANISM(S): Mus musculus 
2015-05-12 | E-GEOD-68718 | biostudies-arrayexpress
TranscriptomicsLRH-1 governs vital transcriptional programs in endocrine sensitive and resistant breast cancer cells: Expression profiling
Tumor characteristics are decisive in the determination of treatment strategy for breast cancer patients. Patients with estrogen receptor-α (ERα) positive breast cancer can benefit from long-term hormonal treatment. Nonetheless, the majority of patients will develop resistance to these therapies. He...
ORGANISM(S): Homo sapiens 
2014-02-27 | E-GEOD-54891 | biostudies-arrayexpress
TranscriptomicsLRH1 silencing inhibits human colon cancer growth.
This study was undertaken to better determine the function of LRH-1 (NR5A2) in the colorectal cancers (CRC) through inducible shRNA-mediated knockdown within well-established CRC cell line Caco-2 Our work is the first to demonstrate that silencing of LRH-1 in established human CRC cell lines impairs...
ORGANISM(S): Homo sapiens 
2015-02-24 | E-GEOD-64695 | biostudies-arrayexpress
ProteomicsSelective modulation of nuclear receptor LRH-1 through target-ing buried and surface regions of the binding pocket
Liver receptor homolog-1 (LRH-1) is a phospholipid-sensing nuclear receptor that has shown promise as a target for alleviat-ing intestinal inflammation and disease states characterized by metabolic dysregulation in the liver. LRH-1 contains an unu-sually large ligand binding pocket, and generating s...
ORGANISM(S): Homo sapiens (Human) 
2022-05-04 | PXD031099 | Pride
Lrh-1 Hdx-ms 
TranscriptomicsLRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function [RNA-Seq]
Two separate pools of three Flox or two Lrh1t-/- pancreas RNA preparations was subjected to the Illumina RNA-seq protocol. Examination of mRNA levels in induced Lrh1 pancreas knockout and wild-type mice.
ORGANISM(S): Mus musculus 
2011-11-30 | E-GEOD-34030 | biostudies-arrayexpress
TranscriptomicsLRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function
This SuperSeries is composed of the following subset Series: GSE34030: LRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function [RNA-Seq] GSE34295: LRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function...
ORGANISM(S): Mus musculus 
2011-12-09 | E-GEOD-34296 | biostudies-arrayexpress
TranscriptomicsGlobal hepatic transcript data from LRH-1 WT and LRH-1 K289R livers
Transcript data from LRH-1 WT and LRH-1 K289R livers from mice fed ad libitum and sacrificed at 7 am We used microarrays to detail the global programme of gene expression underlying hepatic function in ad libitum fed mice. 17-19-week-old mice were fed ad libitum, sacrificed at 7 am, and livers snap-...
ORGANISM(S): Mus musculus 
2014-07-11 | E-GEOD-59304 | biostudies-arrayexpress
TranscriptomicsGlobal hepatic transcript data from LRH-1 WT and LRH-1 K289R jejunums
Transcript data from LRH-1 WT and LRH-1 K289R jejunums from mice fed ad libitum and sacrificed at 7 am We used microarrays to detail the global programme of gene expression underlying jejunal function in ad libitum fed mice. 19-21-week-old mice were fed ad libitum, sacrificed at 7 am, and jejunums s...
ORGANISM(S): Mus musculus 
2014-07-11 | E-GEOD-59303 | biostudies-arrayexpress
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