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TranscriptomicsLysosome-Related Organelles Orchestrate Biogenic Crystal Formation in Pigment Cells
Lysosome-related organelles (LROs) enable cell-type-specific functions by adapting endolysosomal pathways for specialized roles. Here, we show that iridosomes - optically active, guanine crystal-forming organelles in zebrafish iridophores - constitute a previously unrecognized class of LROs. Using t...
ORGANISM(S): Danio rerio 
2026-03-19 | GSE297759 | GEO
TranscriptomicsEffect of hFWE KO on gene expression in mature epidermal organoids
Specialized secretory cells, including keratinocytes in the last viable layers of mammalian epidermis, utilize lysosome-related organelles (LROs) to exocytose distinct cargoes vital for tissue function. Here, we demonstrate that the Flower isoform, hFWE4, a putative Ca2+ channel that permits endocyt...
ORGANISM(S): Homo sapiens 
2025-06-26 | GSE269871 | GEO
UnknownLead Exposure Induces Telomere Instability in Human Cells.
Not available
S-EPMC3694068 | biostudies-literature
UnknownSingle cell RNA analysis of the left-right organizer transcriptome reveals potential novel heterotaxy genes.
Not available
S-EPMC10314903 | biostudies-literature
UnknownCilia function as calcium-mediated mechanosensors that instruct left-right asymmetry.
Not available
S-EPMC9939240 | biostudies-literature
UnknownLysosome-related organelles promote stress and immune responses in C. elegans.
Not available
S-EPMC10499889 | biostudies-literature
UnknownIntraciliary calcium oscillations initiate vertebrate left-right asymmetry.
Not available
S-EPMC4469357 | biostudies-literature
UnknownFluid extraction from the left-right organizer uncovers mechanical properties needed for symmetry breaking.
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S-EPMC10361723 | biostudies-literature
UnknownDisorders of lysosome-related organelle biogenesis: clinical and molecular genetics.
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S-EPMC2755194 | biostudies-literature
UnknownTEADs, Yap, Taz, Vgll4s transcription factors control the establishment of Left-Right asymmetry in zebrafish.
Not available
S-EPMC6759317 | biostudies-literature
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