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GenomicsExpression data from control and LRRC8A knockdown cells
Expression data from control and LRRC8A knockdown cells
PRJNA1424999 | ENA
ProteomicsStructure of a volume-regulated heteromeric LRRC8A/C channel
Volume-regulated anion channels participate in the cellular response to osmotic swelling. These membrane proteins are heteromers of LRRC8 family members whose composition determines permeation properties. Although structures of the obligatory LRRC8A subunit have previously defined the architecture o...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2023-01-03 | PXD035350 | Pride
Lrrc8 Cryo-em Affinity purification Prm Human X-ray chrystallography Exploris 480 Volume-regulated anion channels Nanobody 
TranscriptomicsDisruption of macrophage cell volume drives inflammatory responses and type I interferon signalling
This experiment explored the impact of cell volume increase and regulatory volume decrease (RVD) on the transcriptome of mouse macrophages. Bone marrow-derived macrophages (BMDMs) were isolated from CX3CR1-cre LRRC8A-flox, or littermate wild-type (CX3CR1-cre negative, LRRC8A flox) mice (PMID: 33216...
ORGANISM(S): Mus musculus 
2026-03-15 | E-MTAB-16723 | biostudies-arrayexpress
TranscriptomicsExpression data from control and LRRC8A knockdown cells
To investigate the biological function of LRRC8A and its underlying molecular mechanisms, we performed high-throughput sequencing to analyze the gene expression profiles of control and LRRC8A-knockdown cells.
ORGANISM(S): Homo sapiens 
2026-07-01 | GSE319713 | GEO
GenomicsEffect of SWELL1 (LRRC8a) gene deletion on gene expression in differentiated myotubes
Effect of SWELL1 (LRRC8a) gene deletion on gene expression in differentiated myotubes
PRJNA658609 | ENA
GenomicsDeficient LRRC8A-dependent Volume-Regulated Anion Channel (VRAC) activity is associated with male infertility in mouse and humans
Deficient LRRC8A-dependent Volume-Regulated Anion Channel (VRAC) activity is associated with male infertility in mouse and humans
PRJNA448855 | ENA
GenomicsLRRC8A-containing chloride channel is crucial for cell volume recovery and survival under hypertonic conditions
LRRC8A-containing chloride channel is crucial for cell volume recovery and survival under hypertonic conditions
PRJNA664795 | ENA
GenomicsBulk RNA-seq analysis of wild-type and LRRC8A knockout primary mouse aortic vascular smooth muscle cells
Bulk RNA-seq analysis of wild-type and LRRC8A knockout primary mouse aortic vascular smooth muscle cells
PRJNA1469218 | ENA
OtherLRRC8A-containing chloride channel is crucial for cell volume recovery and survival under hypertonic conditions
Regulation of cell volume is essential for tissue homeostasis and cell viability. In response to hypertonic stress, cells need rapid electrolyte influx to compensate water loss and to prevent cell death in a process known as regulatory volume increase (RVI). However, the molecular component able to ...
ORGANISM(S): Homo sapiens 
2021-05-29 | GSE158316 | GEO
UnknownLRRC8A critically regulates myofibroblast phenotypes and fibrotic remodeling following myocardial infarction.
Not available
S-EPMC9373806 | biostudies-literature
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