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TranscriptomicsWhole genome profiling of liver sinusoidal endothelial cells (LSEC) before and after hepatectomy
compare acute gene expression changes in LSEC after hepatecomy WT C57BL/6N mice were either sham operated or underwent 2/3 hepatectomy. One day after operation, LSEC were isolated. RNA were immediatedly extracted for gene array.
ORGANISM(S): Mus musculus 
2013-08-26 | E-GEOD-50046 | biostudies-arrayexpress
TranscriptomicsNormal and injured liver sinusoidal endothelial cells
Comparison of C57BL/6J 8-10 weeks male mouse liver sinusoidal endothelial cells (LSEC) from normal liver and from liver injured by carbon tetrachloride administration. Keywords: other
ORGANISM(S): Mus musculus 
2004-10-01 | E-GEOD-1689 | biostudies-arrayexpress
UnknownPU.1 drives specification of pluripotent stem cell-derived endothelial cells to LSEC-like cells.
Not available
S-EPMC7809369 | biostudies-literature
TranscriptomicsLSEC: a microenvironment dependent differentiation program in rat including the novel junctional protein Leda-1
Liver sinusoidal endothelium (LSEC) is a prime example for organ-specific microvascular differentiation and functions. Disease-associated capillarization of LSEC in vivo and dedifferentiation of LSEC in vitro indicate the importance of the hepatic microenvironment. To identify the LSEC-specific mole...
ORGANISM(S): Rattus norvegicus 
2010-05-05 | E-GEOD-20375 | biostudies-arrayexpress
TranscriptomicsVEGF-A stimulated gene expression in human liver sinusoidal endothelial cells
Transcriptomic analysis of VEGF-A stimulated liver sinusoidal endothelial cell gene expression. Untreated cells were compared to those treated with VEGF-A. VEGF-A stimulation is critical for normal LSEC phenotype, and the response to liver injury Two conditions: untreated vs. VEGF-A treated. LSEC...
ORGANISM(S): Homo sapiens 
2013-06-01 | E-GEOD-41110 | biostudies-arrayexpress
TranscriptomicsVirally infected LSEC trigger CD8 T cell immunity
Dendritic cell activation through ligation of pattern recognition receptors leading to full functional maturation causes induction of CD8 T cell immunity instead of tolerance through increased delivery of co-stimulatory signals. Here we investigate whether a prototypic organ-resident antigen-present...
ORGANISM(S): Mus musculus 
2009-12-31 | GSE14674 | GEO
UnknownCritical Role of LSEC in Post-Hepatectomy Liver Regeneration and Failure.
Not available
S-EPMC8347197 | biostudies-literature
UnknownLncRNA Airn maintains LSEC differentiation to alleviate liver fibrosis via the KLF2-eNOS-sGC pathway.
Not available
S-EPMC9520944 | biostudies-literature
UnknownEarly and late phases of liver sinusoidal endothelial cell (LSEC) defenestration in mouse model of systemic inflammation.
Not available
S-EPMC11556108 | biostudies-literature
TranscriptomicsGene expression profiles in fetal human liver sinusoidal endothelial cells (LSEC)
Understanding molecular fingerprints of specific cell types is central for defining lineage development, progression, differentiation and pathophysiological perturbations. This study addressed gene expression profiles in freshly isolated fetal human LSEC as well as these LSEC after cell culture. Com...
ORGANISM(S): Homo sapiens 
2020-06-15 | GSE77293 | GEO
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