Sort   by:  
 Page size 
TranscriptomicsTranscription profiling of mouse VP16-CREB transgenics
Expression of VP16-CREB, a constitutively active form of CREB, in hippocampal neurons of the CA1 region lowers the threshold for eliciting the late, persistent phase of long-term potentiation (L-LTP) in the Schaffer collateral pathway. This VP16-CREB-mediated L-LTP differs from the conventional late...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-3965 | biostudies-arrayexpress
TranscriptomicsDNA-methylation of LTP-associated genes.
Long-term potentiation (LTP) of synaptic transmission is recognized as a cellular mechanism for learning and memory storage. Although de novo gene transcription is known to be required in the formation of stable LTP, the molecular mechanisms underlying synaptic plasticity remain elusive.This study i...
ORGANISM(S): Rattus norvegicus 
2017-03-16 | E-MTAB-4919 | biostudies-arrayexpress
ModelsSmolen2018 - Paradoxical LTP maintenance with inhibition of protein synthesis and the proteasome
This is a mathematical model describing the formation of long-term potentiation (LTP) at the Schaffer collateral of CA1 pyramidal cell synapse. The model consists of nine ordinary differential equations that denote synaptic states associated with different degrees of LTP, as well as the levels of re...
2024-09-02 | BIOMD0000000853 | BioModels
MetabolomicsSystematic analyses of lipid mobilization by human lipid transfer proteins

Lipid transfer proteins (LTPs) maintain the specialised lipid compositions of biological membranes, and many are associated with disease. In eukaryotes, they support organellar functions by transporting lipids between compartmentalised metabolic pathways. However, for the majority of the hundreds...

2025-11-14 | MTBLS9567 | MetaboLights
GenomicsThe polyadenylation landscape after in vivo LTP in the rat brain
The polyadenylation landscape after in vivo LTP in the rat brain
PRJEB75352 | ENA
TranscriptomicsThe ability of VSL#3 to restore the age-related deficit in LTP is associated with changes in brain genes expression
A deficit in synaptic plasticity is one of the many changes that occurs with age. Specifically the archetypal model of plasticity, long-term potentiation (LTP), is reduced in hippocampus of middle-aged and aged animals. Several factors are likely to contribute to this deficit including morphologic...
ORGANISM(S): Rattus norvegicus 
2014-04-02 | E-GEOD-51381 | biostudies-arrayexpress
TranscriptomicsActivity-Dependent Regulation of Alternative Cleavage and Polyadenylation (APA) During Hippocampal Long-Term Potentiation (LTP) [RNA-Seq]
This study was aimed at elucidating the mechanisms underlying activity-dependent gene regulation during long-term potentiation (LTP) of mouse hippocampal CA3-CA1 synapses. Transcriptome analysis allowed to identify changes in gene expression and alternative splicing induced 1 hour and 3 hours after ...
ORGANISM(S): Mus musculus 
2018-02-22 | GSE84503 | GEO
TranscriptomicsComparative transcriptome analysis of APPs?-DM and APLP2-KO brains
Despite its key role in Alzheimer pathogenesis, the physiological function(s) of the amyloid precursor protein (APP) and of its proteolytic fragments are still poorly understood. The secreted APPs? ectodomain has been shown to be involved in neuroprotection and synaptic plasticity. The ?-secretase g...
ORGANISM(S): Mus musculus 
2011-05-10 | E-GEOD-27888 | biostudies-arrayexpress
UnknownGliogenic LTP spreads widely in nociceptive pathways.
Not available
S-EPMC6145441 | biostudies-literature
UnknownParadoxical LTP maintenance with inhibition of protein synthesis and the proteasome suggests a novel protein synthesis requirement for early LTP reversal.
Not available
S-EPMC6179370 | biostudies-literature
Sort   by:  
 Page size