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TranscriptomicsThe glycogen scaffolding protein PTG coordinately regulates glycogen and lipid storage
Glycogen and lipid are major storage forms of energy that are tightly regulated by hormones and metabolic signals. Here, we evaluate the role of the glycogenic scaffolding protein PTG/R5 in energy homeostasis. We demonstrate that feeding mice a high-fat diet (HFD) increases hepatic glycogen, corresp...
ORGANISM(S): Mus musculus 
2014-06-13 | E-GEOD-45319 | biostudies-arrayexpress
GenomicsGcn5 and PCAF negatively regulate interferon β production through HAT-independent inhibition of TBK1 [ChIP-Seq]
Gcn5/PCAF dobule knockout (dKO) in MEFs leads to loss of the global H3K9ac, but only affect expression of a small nubmer of genes according to RNA-Seq data. To examine the function of H3K9ac on gene activation, H3K9ac ChIP-Seq was performed. We found that H3K9ac at Transcriptional Start sites (TSSs)...
ORGANISM(S): Mus musculus 
2014-09-03 | E-GEOD-60967 | biostudies-arrayexpress
TranscriptomicsGcn5 and PCAF negatively regulate interferon β production through HAT-independent inhibition of TBK1 [RNA-Seq]
Gcn5/PCAF double knockout (dKO) leads to loss of the global H3K9ac. RNA-Seq was performed to define the changes of gene expression in response to Gcn5/PCAF deletion and H3K9ac loss PCAF-/-;Gcn5f/D MEFs were infected with retroviral Cre to delete Gcn5 to generate Gcn5/PCAF dKO cells, followed by RNA-...
ORGANISM(S): Mus musculus 
2014-09-03 | E-GEOD-60968 | biostudies-arrayexpress
MetabolomicsFecal metabolomic study in patients with choledocholithiasis concurrent with cholangitis

Metabolites associated with the gut microbiota play an important role in the pathogenesis of choledocholithiasis concurrent with cholangitis (CC). This study aims to characterize the fecal metabolite profile of CC patients and to investigate the correlation and balance within the gut cross-domain...

2025-08-11 | MTBLS12772 | MetaboLights
UnknownMicropeptide CIP2A-BP encoded by LINC00665 inhibits triple negative breast cancer progression
Not available
S-SCDT-EMBOJ-2019-102190 | biostudies-other
TranscriptomicsT lymphocytes from Chronic HCV-infected patients express unique pro-apoptotic gene signature.
Although extensive studies have demonstrated the gene expression patterns of antigen-specific CD4+ and CD8+ T-cells during chronic hepatitis C virus (HCV) infection, the transcriptional profiles of global CD4+ and CD8+ T-cells remains unclear. In this report, we recruited 10 long-term (~20 years) tr...
ORGANISM(S): Homo sapiens 
2013-08-19 | E-GEOD-49954 | biostudies-arrayexpress
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