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ProteomicsSynthetic lethal combinations targeting PLK1-CBX8-GPX4 axis with BRAF and EGFR inhibition in BRAF V600E colorectal cancer
Metastatic BRAFV600E colorectal cancer (CRC) confers poor prognosis and run into a bottleneck in the current treatment strategies. To identify regulatory pathways independent of the MAPK pathway in BRAFV600E CRC, we performed CRISPR-Cas9 screening, and and find targeting glutathione peroxidase 4 (GP...
ORGANISM(S): Homo Sapiens 
2024-11-25 | PXD058213 |
MetabolomicsExploring the gut microbiome and serum metabolome interplay in non-functioning pituitary neuroendocrine tumors.

The gut microbiome has emerged as a potential factor in cancer pathogenesis, but its role in non-functioning pituitary neuroendocrine tumors (NF-PitNETs) remains unclear. This study aimed to elucidate gut microbiome and metabolomic alterations in NF-PitNETs by comparing microbial diversity, patho...

2025-06-16 | MTBLS12328 | MetaboLights
UnknownA DNAH17 missense variant causes flagella destabilization and asthenozoospermia.
Not available
S-EPMC7041708 | biostudies-literature
ProteomicsData-independent acquisition-based quantitative proteomics analysis reveals dynamic network profiles during the macrophage inflammatory response.
Understanding of the molecular regulatory mechanisms underlying the inflammatory response isincomplete, especially with respect to the global proteomic response to microbial infection. Data-independent acquisition (DIA)-based quantitative proteomic analysis has been widely applied inproteomics resea...
ORGANISM(S): Mus Musculus 
2019-12-09 | PXD016668 |
UnknownLow-frequency germline variants across 6p22.2-6p21.33 are associated with non-obstructive azoospermia in Han Chinese men.
Not available
S-EPMC4902876 | biostudies-literature
ProteomicsIdentification of candidate microRNA biomarkers of endometriosis in different bodily fluids
Endometriosis is a common gynecological condition that affects approximately 10% of women of reproductive age and up to half of those experiencing infertility. However, there is a lack of reliable noninvasive diagnostic tools for diagnosing endometriosis. This study aims to identify novel biomarkers...
ORGANISM(S): Homo Sapiens 
2025-11-17 | PXD070868 |
UnknownClinical practice guideline for female fertility preservation.
Not available
S-EPMC12907358 | biostudies-literature
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