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MetabolomicsPTER is an N-acetyltaurine hydrolase that regulates feeding and obesity

Taurine is a conditionally essential micronutrient and one of the most abundant amino acids in humans1-3. In endogenous taurine metabolism, dedicated enzymes are involved in biosynthesis of taurine from cysteine as well as the downstream metabolism of secondary taurine metabolites4,5. One such ta...

2024-09-11 | MTBLS10408 | MetaboLights
ProteomicsTransketolase promotes MAFLD by limiting inosine-induced mitochondrial activity (Proteomics)
Metabolic dysfunction-associated fatty liver disease (MAFLD) has a global prevalence of about 25% and no approved therapy. Using metabolomic and proteomic analyses, we identified high expression of hepatic transketolase (TKT), a metabolic enzyme of the pentose phosphate pathway, in human and mouse M...
ORGANISM(S): Homo Sapiens 
2024-02-26 | PXD050130 |
ProteomicsSCN Proteomic Study:electroacupuncture induced circadian control in Suprachiasmatic Nucleus
Recent reports highlight phosphorylation as a major role in the regulation of sleep-wake cycles, to a lesser extent, the phosphoproteome in Suprachiasmatic Nucleus (SCN) is not well understood. We use multiplex tandem mass tag (TMT) - labelling coupled with liquid chromatography-mass spectrometry (L...
ORGANISM(S): Mus Musculus 
2021-10-31 | PXD029450 |
ProteomicsDisruption of MerTK Increases the Efficacy of Checkpoint Inhibitor by Enhancing Ferroptosis and Immune Response in Hepatocellular Carcinoma
To investigate the potentail anti-PD-L1 resistance mechanism in HCC, we examine the different proteins between hepa1-6 and res1-6 tumor cells. Proteins were digested with trypsin and following by high-resolution liquidchromatography-tandem MS(LC-MS/MS) analysis
ORGANISM(S): Mus Musculus 
2023-12-21 | PXD048069 |
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