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MetabolomicsHepatic Metabolomics Investigation in Acute and Chronic Murine Toxoplasmosis
Toxoplasma gondii poses a great threat to human health, with no approved vaccine available for the treatment of T. gondii infection. T. gondii infections are not limited to the brain, and may also affect other organs especially the liver. Identification of host liver molecules or pathways involved i...
2019-08-06 | MTBLS586 | MetaboLights
UnknownDevelopment and Validation of a Polygenic Risk Score for Stroke in the Chinese Population.
Not available
S-EPMC8424497 | biostudies-literature
TranscriptomicsGene expression of human isogenic trisomy 21 induced pluripotent stem cells and derived neurons
Down syndrome (trisomy 21) is the most common genetic cause of intellectual disability, but the precise molecular mechanisms underlying impaired cognition remain unclear. Elucidation of these mechanisms has been hindered by the lack of a model system that contains full trisomy of chromosome 21 (Ts21...
ORGANISM(S): Homo sapiens 
2013-07-09 | E-GEOD-48611 | biostudies-arrayexpress
MetabolomicsSymbiotic bacteria-derived organic acids protect Delia antiqua larvae from entomopathogenic fungal infection

The protection of associated microbiota for their animal hosts against pathogen infection has been studied widely over the last 100 years. However, how those microbes protect the animal host is limitedly investigated. In former studies, body surface microbes of one insect, Delia antiqua,...

2020-11-12 | MTBLS2074 | MetaboLights
ProteomicsDimeric IgA specifically disables intracellular mutated oncodrivers
Despite their long half-life, therapeutic antibodies are considered ineffective against intracellular antigens due to their perceived inability to penetrate epithelial cells. Using recombinant antibodies targeting common mutations in oncogenes, we demonstrate that dimeric IgA, but not the same antib...
ORGANISM(S): Homo Sapiens 
2026-06-12 | PXD044426 | panorama
ProteomicsSpin-driven Enantioselective Regulation of Cyclooxygenase-2 Activity for Rheumatoid Arthritis Therapy via Chiral Gold Nanohelices
Electron-spin dynamics represent an unexplored dimension in enzymatic catalysis, where most regulatory strategies focus on modulating active-site chemistry. Here, we present a spintronic approach that employs chiral gold nanohelices (CAu) as electron spin polarizers to enantiospecifically modulate c...
ORGANISM(S): Mus Musculus 
PXD076742 |
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