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TranscriptomicsExpression data from Tregs purified from WT-CD3KO or IIKO-CD3KO chimeras
Disruption of TCR /MHC class II interactions leads rapidly to alterations of the common CD4 Treg transcriptional signature Self-deprived, non-functional Tregs were compare to fully functional Tregs by microarrays. CD3ε-/- mice were lethally irradiated and their immune system reconstituted with WT mo...
ORGANISM(S): Mus musculus 
2011-02-09 | E-GEOD-27151 | biostudies-arrayexpress
TranscriptomicsExpression data from self-deprived regulatory CD4 T cells
Disruption of TCR /MHC class II interactions leads rapidly to alterations of the common CD4 Treg transcriptional signature Self-deprived, non-functional Tregs were compare to fully functional Tregs by microarrays. Total T cells from the periphery of WT mice were adoptively transferred into CD3ε-/- ...
ORGANISM(S): Mus musculus 
2011-01-20 | E-GEOD-26714 | biostudies-arrayexpress
TranscriptomicsExpression data from Ly-6C- and Ly-6C+ Naive CD4 T cells
The naive CD4 T cell compartment is heterogeneous. Ly-6C- and Ly-6C+ Naive CD4 T cells were compare by microarrays. Ly-6C- and Ly-6C+ Naive CD4 T cells were purified for RNA extraction and hybridization on Affymetrix microarrays.
ORGANISM(S): Mus musculus 
2013-03-01 | E-GEOD-37336 | biostudies-arrayexpress
ProteomicsFasting upregulates the monocarboxylate transporter Mct1 at the rat blood-brain barrier through Ppar d activation
Fasting is increasingly recognized as a potential therapeutic intervention in the field of neurology and psychiatry. However, its impact upon the blood-brain barrier (BBB), which strictly regulates the cerebral uptake of a wide range of endogenous compounds and drugs, is unknown. In this study we us...
ORGANISM(S): Cellular Organisms 
2024-08-15 | PXD044587 | JPOST Repository
TranscriptomicsMosaic perturbation of transcription factors in human retinal organoid development
To begin to understand how TFs regulate retinal cell type identity in human tissues, we established a pooled loss of function (LOF) experiment based on the CROP-seq protocol in developed retinal organoids. We targeted five TFs (OTX2, NRL, CRX, VSX2, and PAX6) that are important for retinal developme...
ORGANISM(S): Homo sapiens 
2023-02-24 | E-MTAB-12622 | biostudies-arrayexpress
TranscriptomicsSingle-cell transcriptome atlas of human retinal organoid development
In order to provide multi-omic resolution to human retinal organoid developmental dynamics, we performed scRNA-seq and scATAC-seq from the same cell suspension across a time course (6-46 weeks) of human retinal organoid development. This data set covers all the retinal organoid scRNA-seq data genera...
ORGANISM(S): Homo sapiens 
2023-03-12 | E-MTAB-12715 | biostudies-arrayexpress
TranscriptomicsSingle-cell chromatin accessibility atlas of human retinal organoid development
In order to provide multi-omic resolution to human retinal organoid developmental dynamics, we performed scRNA-seq and scATAC-seq from the same cell suspension across a time course (6-46 weeks) of human retinal organoid development. This data set covers all the retinal organoid scATAC-seq data gener...
ORGANISM(S): Homo sapiens 
2023-03-12 | E-MTAB-12714 | biostudies-arrayexpress
TranscriptomicsPID-1 is a novel factor that operates during 21U RNA biogenesis in Caenorhabditis elegans
Animal germ cells employ small RNA-based mechanisms to recognize and silence DNA that invades their genome. One of these pathways is named the Piwi:piRNA pathway. Biogenesis of piRNAs is poorly understood. In C. elegans, the piRNA (21U-RNA)-binding Argonaute protein PRG-1 is the only known player ac...
ORGANISM(S): Caenorhabditis elegans 
2014-03-17 | E-GEOD-55309 | biostudies-arrayexpress
UnknownKetamine, Etomidate, and Mortality in Emergency Department Intubations.
Not available
S-EPMC12706683 | biostudies-literature
UnknownA verified genomic reference sample for assessing performance of cancer panels detecting small variants of low allele frequency.
Not available
S-EPMC8051128 | biostudies-literature
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