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TranscriptomicsBroad shifts in gene expression during early postnatal life are associated with shifts in histone methylation patterns
During early postnatal life, extensive changes in gene expression occur concomitantly in multiple major organs, indicating the existence of a common core developmental genetic program. This program includes hundreds of growth-promoting genes that are downregulated with age in liver, kidney, lung, an...
ORGANISM(S): Mus musculus 
2014-08-04 | E-GEOD-49785 | biostudies-arrayexpress
TranscriptomicsTemporal changes of gene expression in rat kidney and lung, and the effect of prior growth inhibition on these changes
Temporal changes of gene expression from 1-wk- to 5-wk-old rat in kidney and lung, and the effect of prior growth inhibition on these genetic changes. In mammals, body growth is rapid in early life but decelerates with age. Somatic growth deceleration is caused by a gradual decline in cell prolifera...
ORGANISM(S): Rattus norvegicus 
2010-09-16 | E-GEOD-16792 | biostudies-arrayexpress
TranscriptomicsSpatial and Temporal Regulation of Gene Expression in the Mammalian Growth Plate
To explore the mechanisms responsible for spatial and temporal regulation of the growth plate, we microdissected postnatal rat growth plates into their constituent zones and then used microarray analysis to characterize the changes in gene expression that occur as chondrocytes undergo spatially-asso...
ORGANISM(S): Rattus norvegicus 
2010-02-22 | E-GEOD-16981 | biostudies-arrayexpress
TranscriptomicsEvidence that variation in adult body size among mammalian species is achieved by modulating the pace of a growth-regulating genetic program
Body size varies enormously among mammalian species. In small mammals, body growth is typically suppressed rapidly, within weeks, whereas in large mammals, growth is suppressed slowly, over years, allowing for a greater adult size. We recently reported evidence that body growth suppression in rodent...
ORGANISM(S): Ovis aries 
2014-05-19 | E-GEOD-48916 | biostudies-arrayexpress
TranscriptomicsSpatial Regulation of Gene Expression in Articular Cartilage Assessed by Laser Captured Microdissection and Microarray
We used laser capture microdissection to isolate different zones of the articular cartilage from proximal tibiae of 1-week old mice, and used microarray to analyze global gene expression. Bioinformatic analysis corroborated previously known signaling pathways, such as Wnt and Bmp signaling, and impl...
ORGANISM(S): Mus musculus 
2014-10-20 | E-GEOD-51994 | biostudies-arrayexpress
UnknownRelationship Between Severity of Ischemia and Coronary Artery Disease for Different Stress Test Modalities in the ISCHEMIA Trial.
Not available
S-EPMC11658795 | biostudies-literature
UnknownTwo Phase 3 Trials of Gantenerumab in Early Alzheimer's Disease.
Not available
S-EPMC10794000 | biostudies-literature
UnknownInitial Invasive or Conservative Strategy for Stable Coronary Disease.
Not available
S-EPMC7263833 | biostudies-literature
UnknownFactors Associated With Coronary Angiography Performed Within 6 Months of Randomization to the Conservative Strategy in the ISCHEMIA Trial.
Not available
S-EPMC11187765 | biostudies-literature
UnknownHealth-Status Outcomes with Invasive or Conservative Care in Coronary Disease.
Not available
S-EPMC7261489 | biostudies-literature
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