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TranscriptomicsDissecting modes of action of non-genotoxic carcinogens in primary mouse hepatocytes.
Under REACH, the European Community Regulation on chemicals, the testing strategy for carcinogenicity is generally based on in vitro and in vivo genotoxicity assays. Given that non-genotoxic carcinogens are negative for genotoxicity, this class of carcinogens will not be detected. Therefore, alterna...
ORGANISM(S): Mus musculus 
2012-06-25 | E-GEOD-35058 | biostudies-arrayexpress
TranscriptomicsMicroRNA and mRNA biomarkers for short-term in vivo genotoxic and non-genotoxic carcinogen classification
Many innovative techniques and scientific improvements are available to tackle societal concerns, like public health safety and confining the risk of cancerous exposure to chemicals, but have not been thoroughly tested and implicated yet. We investigated if microRNA and mRNA transcription profiles c...
ORGANISM(S): Mus musculus 
2014-04-01 | E-GEOD-43977 | biostudies-arrayexpress
TranscriptomicsMicroRNA and mRNA biomarkers for short-term in vivo genotoxic and non-genotoxic carcinogen classification
Many innovative techniques and scientific improvements are available to tackle societal concerns, like public health safety and confining the risk of cancerous exposure to chemicals, but have not been thoroughly tested and implicated yet. We investigated if microRNA and mRNA transcription profiles c...
ORGANISM(S): Mus musculus 
2014-04-01 | E-GEOD-43847 | biostudies-arrayexpress
TranscriptomicsGene expression data from precision cut human liver slices treated to diclofenac
Drug-induced liver injury (DILI) is an important clinical problem. Here we used a genomics approach to establish the critical drug-induced toxicity pathways that act in synergy with the pro-inflammatory cytokine tumor necrosis factor (TNF) to cause cell death of liver HepG2 cells. Transcriptomics o...
ORGANISM(S): Homo sapiens 
2014-01-22 | E-GEOD-54255 | biostudies-arrayexpress
TranscriptomicsExpression data from primary mouse hepatocytes treated with Diclofenac
Drug-induced liver injury (DILI) is an important clinical problem. Here we used a genomics approach to establish the critical drug-induced toxicity pathways that act in synergy with the pro-inflammatory cytokine tumor necrosis factor M-oM-^AM-! (TNFM-oM-^AM-!) to cause cell death of liver HepG2 cell...
ORGANISM(S): Mus musculus 
2014-01-22 | E-GEOD-54256 | biostudies-arrayexpress
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