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TranscriptomicsGenomic responses to arsenic in Synechocystis
Arsenic is an ubiquitous contaminant and a toxic metalloid which presents two main redox states in nature: arsenite [AsIII] and arsenate [AsV]. Arsenic resistance in Synechocystis sp. strain PCC 6803 is mediated by the arsBHC operon and two additional arsenate reductases encoded by the arsI1 and ars...
ORGANISM(S): Synechocystis sp. PCC 6803 
2014-05-13 | E-GEOD-51383 | biostudies-arrayexpress
MetabolomicsOverexpression of the vascular brassinosteroid receptor BRL3 confers drought resistance without penalizing plant growth

Drought represents a major threat to food security. Mechanistic data describing plant responses to drought have been studied extensively and genes conferring drought resistance have been introduced into crop plants. However, plants with enhanced drought resistance usually display lower growth, hi...

2021-05-17 | MTBLS2289 | MetaboLights
TranscriptomicsscRNA-seq of human Tfh, Tfr and Treg cells sorted from Tonsil, Iliac Lymph Node and PBMCs
The datasets were obtained to investigate the transcriptional profile of Tfh, Tfr and Treg cells isolated from different human tissues. The comparison between lymphoid tissues with different frequency of the most mature Tfh and Tfr cells allows the investigation of maturation as well as tissue adapt...
ORGANISM(S): Homo sapiens 
2021-04-22 | E-MTAB-10364 | biostudies-arrayexpress
TranscriptomicsGenome-wide differences in expression and alternative splicing in human dendritic cells upon E.coli challenge
The immune system relies on the plasticity of its components to produce appropriate responses to frequent environmental challenges. Dendritic cells (DCs) are critical initiators of innate immunity and orchestrate the later and more specific adaptive immunity. The generation of diversity in transcrip...
ORGANISM(S): Homo sapiens 
2012-11-28 | E-GEOD-42561 | biostudies-arrayexpress
Transcriptomicsbulk RNA-seq of Anopheles gambiae hemocytes, guts, and carcasses after blood-feeding, Plasmodium berghei infection, or sugar feeding
Anopheline mosquitoes transmit Plasmodium parasites to humans, and are responsible for an estimated 219 million cases of malaria, leading to over 400,000 deaths annually. The mosquito’s immune system limits Plasmodium infection in several ways, and hemocytes, the insect white blood cells, are key pl...
ORGANISM(S): Anopheles gambiae 
2020-08-27 | E-MTAB-9241 | biostudies-arrayexpress
TranscriptomicsscRNA-seq of Anopheles gambiae hemocytes after blood-feeding, Plasmodium berghei infection, or sugar feeding
Anopheline mosquitoes transmit Plasmodium parasites to humans, and are responsible for an estimated 219 million cases of malaria, leading to over 400,000 deaths annually. The mosquito’s immune system limits Plasmodium infection in several ways, and hemocytes, the insect white blood cells, are key pl...
ORGANISM(S): Aedes aegypti 
2020-08-27 | E-MTAB-9240 | biostudies-arrayexpress
TranscriptomicsExpression profile pAP1-AP1-GR ap1cal inflorescences - time series (days)
This experiment describes gene expression after the activation of APETALA1-GR, to study and identify AP1 target genes. We used a pAP1:AP1-GR ap1 cal line to induce a synchronized response activating the AP1-GR fusion protein in ap1 cal inflorescence-like meristems through dexamethasone treatment. T...
ORGANISM(S): Arabidopsis thaliana 
2014-01-01 | E-GEOD-47981 | biostudies-arrayexpress
TranscriptomicsIdentification of Yeast Genes that Confer Resistance to Chitosan Oligosaccharide (COS) Using Chemogenomics
Abstract: Chemogenomic fitness assays were combined with a transcriptome analysis to understand both the mode of action and the mechanisms of resistance to Chitosan oligosaccharides (COS). COS are deacetylated chitin compounds, with antimicrobial properties, that are presumed to act by disrupting t...
ORGANISM(S): Saccharomyces cerevisiae 
2012-12-22 | E-GEOD-32888 | biostudies-arrayexpress
TranscriptomicsComparison of miRNA profile in body fluids (plasma and bronchoalveolar fluid cytology)
The objective is to obtain miRNA representative signatures both in plasma and bronchoalveolar cell fraction that could serve as biomarker in respiratory diseases. The identification of new less invasive biomarkers is necessary to improve the detection and prognostic outcome of respiratory pathologic...
ORGANISM(S): Homo sapiens 
2011-10-20 | E-GEOD-33045 | biostudies-arrayexpress
TranscriptomicsExpression data from longissimus dorsi of backcross Iberian x Landrace individuals
The integration of the results of QTL fine-mapping with microarray expression data offers a promising tool for understanding the genetic mechanisms influencing complex traits as fatty acid composition in pigs. The expression level of each probe may be treated as a quantitative trait and the marker g...
ORGANISM(S): Sus scrofa 
2013-11-22 | E-GEOD-52626 | biostudies-arrayexpress
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