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TranscriptomicsSomatic Gain-of-Function mTOR mutation in Clonally Expanded T-lymphocytes Associated with Chronic Graft-Versus-Host Disease
Graft-versus-host-disease (GvHD) is the main complication of allogeneic hematopoietic stem cell transplantation (HSCT). Here we report studies of a patient with chronic GVHD (cGVHD) carrying persistent CD4+ T cell clonal expansion which harbored somatic mTOR, NFKB2, and TLR2 mutations. Functional an...
ORGANISM(S): Homo sapiens 
2020-04-12 | E-MTAB-8911 | biostudies-arrayexpress
TranscriptomicsscRNAseq of immune cells of patients with chronic graft-versus-host disease
In this study, we investigated somatic mutations in T cells in patients with various hematological disorders. To analyze immune cell phenotypes with somatic mutations, we performed scRNA+TCRab sequencing from 9 patients with chronic GVHD and clonal expansions of CD4+ or CD8+ T cells based on T cell ...
ORGANISM(S): Homo sapiens 
2024-04-10 | E-MTAB-13419 | biostudies-arrayexpress
TranscriptomicsAIRE-deficient CD8+CD28low regulatory T lymphocytes fail to control experimental colitis
Mutations in the gene encoding the transcription factor AutoImmune REgulator (AIRE) are responsible for the ‘Autoimmune PolyEndocrinopathy Candidiasis Ecodermal Dystrophy’ syndrome. AIRE directs expression of tissue restricted antigens in the thymic medulla and in lymph node stromal cells and thereb...
ORGANISM(S): Mus musculus 
2011-06-22 | E-GEOD-30129 | biostudies-arrayexpress
TranscriptomicsSingle-cell characterization of immune aplastic anemia reveals convergence of adaptive and innate immunity: in vitro
Immune aplastic anemia (AA) is a life-threatening bone marrow (BM) failure disorder driven by an autoimmune T cell attack against the hematopoietic stem and progenitor cells (HSPCs). However, the autoantigen targets and the role of other immune cells are unknown. Here, by combining scRNA+TCRαβ-seq, ...
ORGANISM(S): Homo sapiens 
2024-12-12 | E-MTAB-13484 | biostudies-arrayexpress
TranscriptomicsSomatic mutations in lymphocytes in patients with immune-mediated aplastic anemia
In this study, we investigated somatic mutations of CD4+ and CD8+ T cells in patients with immune-mediated aplastic anemia (AA). To understand the role of mutations, we performed single-cell level analysis of 6 longitudinal samples of 2 AA patients carrying STAT3 or KRAS and other mutations in CD8+ ...
ORGANISM(S): Homo sapiens 
2021-03-24 | E-MTAB-9969 | biostudies-arrayexpress
UnknownMultipotent mesenchymal stromal cells synergize with costimulation blockade in the inhibition of immune responses and the induction of Foxp3+ regulatory T cells.
Not available
S-EPMC4250203 | biostudies-literature
UnknownRapid Cytokine Release Assays for Analysis of Severe Acute Respiratory Syndrome Coronavirus 2-Specific T Cells in Whole Blood.
Not available
S-EPMC8807220 | biostudies-literature
UnknownAutoimmune regulator (AIRE)-deficient CD8+CD28low regulatory T lymphocytes fail to control experimental colitis.
Not available
S-EPMC3145727 | biostudies-literature
UnknownLong-Term GAD-alum Treatment Effect on Different T-Cell Subpopulations in Healthy Children Positive for Multiple Beta Cell Autoantibodies.
Not available
S-EPMC9159828 | biostudies-literature
MetabolomicsA metabolite roadmap of the wood-forming tissue in Populus tremula (GC-MS assay; Wood ring and extraxylary tissue)

Wood, or secondary xylem, is the product of xylogenesis, a developmental process that begins with the proliferation of cambial derivatives and ends with mature xylem fibers and vessels with lignified secondary cell walls. Fully mature xylem has undergone a series of cellular processes, including ...

2020-09-01 | MTBLS1796 | MetaboLights
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