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MetabolomicsApoptosis-inducing effects of aqueous extract of Eleutherococcus senticosus on non-small cell lung cancer cell proliferation

Non-small cell lung cancer is a malignant tumor with high morbidity and mortality worldwide. Eleutherococcus senticosus can induce apoptosis in non-small cell lung cancer cells, but the mechanism remains unclear. This study aimed to elucidate the role of Eleutherococcus senticosus in inducing apo...

2025-05-12 | MTBLS10545 | MetaboLights
OtherIdentifying novel targets of oncogenic EGF receptor signaling in lung cancer through global phosphoproteomics.
Data from ProteomeXchange, PXD ID: PXD001101. Experiment: pST_SILAC_R1a, file: H3255_pST_SILAC_R1_F4_a.mzml. Published as part of Proteomics. 2015 Jan;15(2-3):340-55 . From the Abstract: {{i}} . We sought to identify the immediate direct and indirect phosphorylation targets of mutant EGFRs in lung ...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32320007613 | GPMDB
Resource Reanalysis 
TranscriptomicsRNA-seq comparison of fetal lung and cultured fetal lung derived organoids with pluripotent stem cell derived lung organoids
Underdeveloped lungs are the primary cause of death in premature infants, however, little is known about stem and progenitor cell maintenance during human lung development. In this study, we have identified that FGF7, Retinoic Acid and CHIR-99021, a small molecule that inhibits GSK3 to activate Wnt ...
ORGANISM(S): Homo sapiens 
2018-11-17 | E-MTAB-6023 | biostudies-arrayexpress
TranscriptomicsGene Expression Patterns that Predict Sensitivity to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Lung Cancer Cell Lines and Human Lung Tumors
Global gene expression data were generated from cultured non small cell lung cancer cell lines (NSCLC), normalized using MAS 5.0, filtered and used to predict response of cells to EGFR inhibition Gene expression data from additional cell lines and tumors was used to validate the predictive algorithm...
ORGANISM(S): Homo sapiens 
2011-08-31 | E-GEOD-31625 | biostudies-arrayexpress
ProteomicsTriple SILAC exosomal quantitative proteomic analysis
Exosomes are 30-100 nm sized membrane vesicles released by cells into extracellular space and mediate the intercellular communication via transfer of proteins and RNAs. To better understand the function of these microvesicles in lung carcinogenesis, we employed a Triple SILAC quantitative proteomic ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-02 | MSV000079882 | MassIVE
TranscriptomicsTranscriptomic analysis of cultured lung epithelial cells exposed to multiwalled carbon nanotubes (Mitsui7)
There is great interest in substituting animal with in vitro experimentation in human health risk assessment, but there are rather few comparisons of in vitro and in vivo biological responses to engineered nanomaterials (ENM). We used high-content genomics tools, to compare in vivo pulmonary respon...
ORGANISM(S): Mus musculus 
2015-05-05 | E-GEOD-46999 | biostudies-arrayexpress
TranscriptomicsGenetic Influences on Asthma Susceptibility in Developing Lung
Whole transcriptome assay of whole lung of rat from 3 genetic strains (Lewis, Fisher, Brown Norway) at 3 postnatal time points (postnatal days 1, 7, 14). Total RNA obtained from whole lung of rat from 3 genetic strains and 3 postnatal time points in (mainly) quadruplicate measurements per strain and...
ORGANISM(S): Rattus norvegicus 
2010-06-24 | E-GEOD-19666 | biostudies-arrayexpress
TranscriptomicsMethylation arrays (MethylationEPIC) of human lung epithelial BEAS-2B cells exposed to reduced graphene oxide
Nanomaterials have lots of promising applications, and concern has risen about their impact to human health. Here, we have analyzed the genome-wide DNA methylation changes associated to the exposure to reduced graphene oxide (rGO) in human lung epithelial cells. Six conditions were assayed, with two...
ORGANISM(S): Homo sapiens 
2019-09-16 | E-MTAB-7719 | biostudies-arrayexpress
ProteomicsLung proteome of the AAV-DTR/DT mouse model of acute epithelial lung injury
Injury of the lung epithelium is one of the initial events driving acute lung diseases such as acute lung injury and acute respiratory distress syndrome. Repeated epithelial injury followed by aberrant repair leads to fibroblast activation and extracellular matrix deposition and is therefore conside...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2021-12-04 | MSV000088510 | MassIVE
ProteomicsTargeting Focal Adhesion Kinase overcomes erlotinib resistance in smoke induced lung cancer by altering phosphorylation of Epidermal Growth Factor Receptor
Cigarette smoking is the leading cause for non-small cell lung carcinoma (NSCLC). Tyrosine kinase inhibitors (TKIs) targeting EGFR are in clinical practice and has benefitted patients with EGFR mutations. However, EGFR based targeted therapies have shown limited success in smokers. Identification of...
ORGANISM(S): Homo sapiens (Human) 
2018-03-21 | PXD006705 | Pride
Epidermal growth factor receptor Drug resistance Nsclc Cigarette smoke Phosphoproteomics 
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