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TranscriptomicsRole of Notch receptors in ozone induced lung injury in mice
Ozone is a highly toxic air pollutant and global health concern. Mechanisms of genetic susceptibility to ozone-induced lung inflammation are not completely understood. We hypothesized Notch3 and Notch4 are important determinants of susceptibility to ozone-induced lung inflammation. Wild type (WT)...
ORGANISM(S): Mus musculus 
2015-02-24 | E-GEOD-58244 | biostudies-arrayexpress
TranscriptomicsInflammasome-regulated cytokines are critical mediators of lung injury in humans.
A microarray analysis involving whole blood samples isolated from critically ill patients in the medical intensive care unit at Brigham and Women's Hospital. Four groups of intubated subjects undergoing mechanical ventilation were recruited for the study: those with sepsis alone (Sepsis), those wit...
ORGANISM(S): Homo sapiens 
2012-07-10 | E-GEOD-32707 | biostudies-arrayexpress
Transcriptomicspreparative changes in rat intestine and lung for birth
To identify genes important in fetal preparation for birth. Transcript profiling using microarray analysis was performed using lung and intestine RNA from a single animal from each of 10 litters at a given gestational age. Array experiments were performed by the Genomics CoreLab, Cambridge Comprehen...
ORGANISM(S): Rattus norvegicus 
2010-11-21 | E-GEOD-16849 | biostudies-arrayexpress
TranscriptomicsLung gene expression analysis of WT, Nlrp3-, Asc-deficient mice in Streptococcus pneumoniae D39 and ATCC6303 infection
Streptococcus (S.) pneumoniae is the most frequently isolated causative pathogen community-acquired pneumonia, a leading cause of mortality worldwide. We investigated the role of the inflammasome sensor NLRP3 and the inflammasome adapter ASC during S. pneumoniae pneumonia. Detailed analysis of the e...
ORGANISM(S): Mus musculus 
2014-11-27 | E-GEOD-42464 | biostudies-arrayexpress
GenomicsPyroptosis of pulmonary fibroblasts through NLRC4 inflammasome leads to acuterespiratory failure
Pyroptosis of pulmonary fibroblasts through NLRC4 inflammasome leads to acuterespiratory failure
PRJNA1120488 | ENA
TranscriptomicsGene expression profile in the lung of mice during pneumococcal pneumonia: WT vs NLRP3 inflammasome component-deficient mice
Inflammasomes are multiprotein platforms of caspase-1 activation. The NLRP3 inflammasome is composed of NLRP3, ASC, and procaspase-1. This inflammasome is activated by various endogenous and exogenous stimuli, including pneumococci, and protects from a variety of microbial pathogens. In the present ...
ORGANISM(S): Mus musculus 
2014-12-31 | GSE56653 | GEO
GenomicsDietary saturated fatty acids promote lung myeloid cell inflammasome activation and IL-1β-mediated inflammation in mice and humans
Dietary saturated fatty acids promote lung myeloid cell inflammasome activation and IL-1β-mediated inflammation in mice and humans
PRJNA1265253 | ENA
UnknownActivation of NLRP3 inflammasome in lung epithelial cells triggers radiation-induced lung injury.
Not available
S-EPMC9872296 | biostudies-literature
UnknownAn Allergic Lung Microenvironment Suppresses Carbon Nanotube-Induced Inflammasome Activation via STAT6-Dependent Inhibition of Caspase-1.
Not available
S-EPMC4474696 | biostudies-literature
UnknownAutophagy Protects Against Developing Increased Lung Permeability and Hypoxemia by Down Regulating Inflammasome Activity and IL-1β in LPS Plus Mechanical Ventilation-Induced Acute Lung Injury.
Not available
S-EPMC7033480 | biostudies-literature
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