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TranscriptomicsEmbryonic stem cells exhibit mRNA isoform-specific translational regulation
Investigation of the differential translation rates of individual mRNA variants in embryonic stem cells (ESCs) and in ESC-derived neural precursor cells (NPCs) using polysome profiling coupled to RNA sequencing. Mouse ESCs were differentiated into Sox1-positive neural precursor cells (NPCs). One rep...
ORGANISM(S): Mus musculus 
2016-01-26 | E-GEOD-73467 | biostudies-arrayexpress
UnknownSingle-cell transcriptomes and whole-brain projections of serotonin neurons in the mouse dorsal and median raphe nuclei.
Not available
S-EPMC6812963 | biostudies-literature
UnknownPractical issues regarding implementing a randomized clinical trial in a homeless population: strategies and lessons learned.
Not available
S-EPMC5498931 | biostudies-literature
UnknownIntegrating smoking cessation and alcohol use treatment in homeless populations: study protocol for a randomized controlled trial.
Not available
S-EPMC4552980 | biostudies-literature
UnknownMutations in the RSK2(RPS6KA3) gene cause Coffin-Lowry syndrome and nonsyndromic X-linked mental retardation.
Not available
S-EPMC2714973 | biostudies-literature
ProteomicsContext-dependent and disease-specific diversity in stress granules formed from preexisting protein interactions
Affinity-capture proteomics studies using endogenously tagged G3BP1 with APEX2 to capture the stress granule proteome at steady state and upon stress induction. This was done in 293T cells as well as induced pluripotent stem cells differentiated into neuronal progenitor cells.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000081554 | MassIVE
TranscriptomicsExpression data from Saccharomyces cerevisiae treated with Small Molecule Enhancers of Rapamycin (SMERs)
The target of rapamycin (TOR) plays a central role in eukaryotic cell growth control. With prevalent hyper-activation of the mTOR pathway in human cancers, novel strategies to enhance TOR pathway inhibition are highly desirable. We used a yeast-based high-throughput chemical genetic screen to identi...
ORGANISM(S): Saccharomyces cerevisiae 
2010-07-29 | E-GEOD-22269 | biostudies-arrayexpress
ProteomicsTracheal aspirate proteome from hospitalized patients infected with SARS-CoV-2
Tracheal aspirate was collected from intubated patients with SARS-CoV-2 infections or for reasons not related to COVID-19 (controls). The proteins were extracted using the MPLEx method. Proteins were digested with trypsin and analyzed by LC-MS/MS on a Thermo Q Exactive HF-X. Data was searched with M...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-06-06 | MSV000089614 | MassIVE
TranscriptomicsExpression data from Saccharomyces cerevisiae Met30 temperature-sensitive strain
The target of rapamycin (TOR) plays a central role in eukaryotic cell growth control. With prevalent hyper-activation of the mTOR pathway in human cancers, novel strategies to enhance TOR pathway inhibition are highly desirable. We used a yeast-based high-throughput chemical genetic screen to identi...
ORGANISM(S): Saccharomyces cerevisiae 
2011-06-30 | E-GEOD-22270 | biostudies-arrayexpress
TranscriptomicsExpression data from Saccharomyces cerevisiae temperature-sensitive strains specific for SCF core components (Skp1, Cullin (Cdc53), E2 enzyme (Cdc34)) and the F-box protein Cdc4.
The target of rapamycin (TOR) plays a central role in eukaryotic cell growth control. With prevalent hyper-activation of the mTOR pathway in human cancers, novel strategies to enhance TOR pathway inhibition are highly desirable. We used a yeast-based high-throughput chemical genetic screen to identi...
ORGANISM(S): Saccharomyces cerevisiae 
2011-06-30 | E-GEOD-22271 | biostudies-arrayexpress
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