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TranscriptomicsIdentification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene
To comprehensively characterize microRNA (miRNA) expression in breast cancer, we performed the first extensive next-generation sequencing expression analysis of this disease. We sequenced small RNA from tumors with paired samples of normal and tumor-adjacent breast tissue. Our results indicate that ...
ORGANISM(S): Homo sapiens 
2012-07-06 | E-GEOD-39162 | biostudies-arrayexpress
TranscriptomicsIdentification of subtypes in HER2-positive breast cancer reveals a gene signature prognostic of outcome
Purpose HER2 gene amplification or protein overexpression (HER2+) defines a clinically challenging subgroup of breast cancer with variable prognosis and response to therapy. We aimed to investigate the heterogeneous biological appearance and clinical behavior of HER2+ tumors using molecular profilin...
ORGANISM(S): Homo sapiens 
2010-03-16 | E-GEOD-18328 | biostudies-arrayexpress
TranscriptomicsHigh-resolution genomic profiling of male breast cancer reveals differences hidden behind the similarities with female breast cancer.
Male breast cancer (MBC) is extremely rare and poorly characterized on the molecular level. Using high-resolution genomic data, we aimed to characterize MBC by genomic imbalances and to compare it with female breast cancer (FBC), and further to investigate whether the genomic profiles hold any progn...
ORGANISM(S): Homo sapiens 
2016-07-03 | E-GEOD-50512 | biostudies-arrayexpress
TranscriptomicsGenomic Subtypes of Breast Cancer Identified by Array Comparative Genomic Hybridization
Breast cancer is a profoundly heterogeneous disease with respect to biological and clinical behavior. Gene expression profiling has been used to dissect this complexity and stratify tumors into intrinsic gene expression subtypes associated with distinct biology, patient outcome and different genomic...
ORGANISM(S): Homo sapiens 
2010-06-23 | E-GEOD-22133 | biostudies-arrayexpress
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