High-resolution genomic profiling of male breast cancer reveals differences hidden behind the similarities with female breast cancer.

ABSTRACT: Male breast cancer (MBC) is extremely rare and poorly characterized on the molecular level. Using high-resolution genomic data, we aimed to characterize MBC by genomic imbalances and to compare it with female breast cancer (FBC), and further to investigate whether the genomic profiles hold any prognostic infor- mation. Fifty-six fresh frozen MBC tumors were analyzed using high-resolution tiling BAC arrays. Significant regions in common between cases were assessed using Genomic Identification of Significant Targets in Cancer (GISTIC) analysis. A publicly available genomic data set of 359 FBC tumors was used for reference purposes. The data revealed a broad pattern of aberrations, confirming that MBC is a heterogeneous tumor type. Genomic gains were more common in MBC than in FBC and often i

ORGANISM(S): Homo sapiens

SUBMITTER: Ida Johansson 

PROVIDER: E-GEOD-50512 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress