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TranscriptomicsExploiting microRNA and mRNA profiles generated in vitro from carcinogen-exposed primary mouse hepatocytes for predicting in vivo genotoxicity and carcinogenicity (miRNA)
The well-defined battery of in vitro systems applied within chemical cancer risk assessment is often characterised by a high false-positive rate, thus repeatedly failing to correctly predict the in vivo genotoxic and carcinogenic properties of test compounds. Toxicogenomics, i.e. mRNA-profiling, has...
ORGANISM(S): Mus musculus 
2016-06-28 | E-GEOD-72014 | biostudies-arrayexpress
TranscriptomicsGene expression in experimentally injured and control mouse spinal cords
This laboratory works on selectins and their carbohydrate ligands in lymphocyte homing and inflammation. The lab also studies heparin-degrading endosulfatases and their roles in regulating the interactions of growth factors and morphogens with proteoglycans. The purpose of the experiment is to exami...
ORGANISM(S): Mus musculus 
2011-02-17 | E-GEOD-27359 | biostudies-arrayexpress
TranscriptomicsAnalysis of miRNA profiles in CD4+ T-lymphocytes following exposure to HIV-1
Assessment of the extent to which the altered profiles of miRNA expression influence viral replication and latency, as well as the efficiency of host defenses, may be useful for understanding the basis of the HIV-1-related alterations in cellular physiology and immunologic control. To this end, thre...
ORGANISM(S): Homo sapiens 
2011-11-08 | E-GEOD-33514 | biostudies-arrayexpress
TranscriptomicsEvaluating microRNA profiles reveals discriminative responses following genotoxic or non-genotoxic carcinogen exposure in primary mouse hepatocytes [Exiqon]
The study investigated differential miRNA changes in primary mouse hepatocyte following 24 and 48 hours of exposure to aflatoxin B1, cisplatin, benzo(a)pyrene, 2,3,7,8-tetrachloordibenzo-p-dioxine, cyclosporin A or Wy-14,643 or their responsive solvent. Three (four for Wy-14,643) biological replica...
ORGANISM(S): Mus musculus 
2015-05-18 | E-GEOD-57082 | biostudies-arrayexpress
OtherA combined omics approach to generate the surface atlas of human naive CD4+ T cells during early TCR activation.
Data from ProteomeXchange, PXD ID: PXD001432. File: SUK5557A8MA2__008-Spender2_3hP SUK5557A8MA2-40-215297.mzml. Published as part of . From the Abstract: {{i}} ... Periodate oxidation and aniline-catalyzed oxime ligation (PAL) technology was applied with subsequent quantitative LC-MS/MS (PAL-qLC-MS...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32310020145 | GPMDB
Resource Reanalysis 
TranscriptomicsExploiting microRNA and mRNA profiles generated in vitro from carcinogen-exposed primary mouse hepatocytes for predicting in vivo genotoxicity and carcinogenicity
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2016-06-28 | E-GEOD-72088 | biostudies-arrayexpress
TranscriptomicsCharacterization of CD57+PD1- CD4 T cells
We have identified a CD57+PD1- CD4 T cell phenotype at the time of transplantation that strongly correlates with subsequesnt development of belatacept-resistant rejection. In this study, we used microarray to determine which genes were upregulated in CD57+ compared to CD57- CD4 T cells. Peripheral b...
ORGANISM(S): Homo sapiens 
2016-01-08 | E-GEOD-64805 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human monocyte derived dendritric cells matured with Galectin-1 or LPS vs controls
Human monocyte derived dendritic cells matured via galectin-1 or LPS. Experiment Overall Design: 4 conditions with 3 replicates of each include control or intreated immature MDDCS, galectin-1 treated MDDCs, LPS treated MDDCs, and vehicle control MDDCs. (each replicate is from a distinct DONOR). Dend...
ORGANISM(S): Homo sapiens 
2007-10-26 | E-GEOD-4984 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression profiles in NOD and Idd9 CD4+ T cells
Nonobese diabetic (NOD) mice congenic for B10 derived genes in the Idd9 region of chromosome 4 are highly protected from the development of diabetes. In order to identify possible candidate genes within the Idd9 susceptibility region and possible downstream mediators of protection, we compared gene ...
ORGANISM(S): Mus musculus 
2012-02-01 | E-GEOD-35482 | biostudies-arrayexpress
TranscriptomicsRNAseq of tumor samples from CT26 syngeneic mouse treated with a PD-L1 and CTLA-4 immunotherapy combination
The ability to modulate immune-inhibitory pathways using checkpoint blockade antibodies such as PD-1, PD-L1, and CTLA-4 represents a significant breakthrough in cancer therapy in recent years. This has driven interest in identifying small-molecule-immunotherapy combinations to increase the proportio...
ORGANISM(S): Mus musculus 
2020-04-16 | E-MTAB-7777 | biostudies-arrayexpress
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