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MetabolomicsLyme Disease Biosignature Training (95 MFs)
Not available
ORGANISM(S): Homo sapiens 
ST000888 | MetabolomicsWorkbench
MetabolomicsHost Metabolic Response in Early Lyme Disease
Not available
ORGANISM(S): Homo sapiens 
ST001223 | MetabolomicsWorkbench
TranscriptomicsSerum Inflammatory Mediators as Markers of Human Lyme Disease Activity
Chemokines and cytokines are key signaling molecules that orchestrate the trafficking of immune cells, direct them to sites of tissue injury and inflammation and modulate their states of activation and effector cell function. We have measured, using a multiplex-based approach, the levels of 58 immun...
ORGANISM(S): Homo sapiens 
2014-04-25 | E-GEOD-55815 | biostudies-arrayexpress
MetabolomicsMetabolic Response in Patients with Post-Treatment Lyme Disease Symptoms/Syndrome
Not available
ORGANISM(S): Homo sapiens 
ST001391 | MetabolomicsWorkbench
TranscriptomicsIdentification of a Molecular Signature for Acute Lyme Disease by Human Transcriptome Profiling
Lyme disease is challenging to diagnose, as clinical manifestations are variable and current tools to detect nucleic acid or antibody responses from Borrelia burgdorferi infection have low sensitivity. Here we conducted the first study of the global transcriptome of patients with Lyme disease to id...
ORGANISM(S): Homo sapiens 
2016-02-15 | E-GEOD-63085 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse model of Lyme disease
The murine model of Lyme disease provides a unique opportunity to study the localized host response to similar stimulus, B. burgdorferi, in the joints of mice destined to develop severe arthritis (C3H) or mild disease (C57BL/6). Pathways associated with the response to infection and the development...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-6055 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human umbilical vein endothelial cells treated with Interferon-gamma (IFN-g), Borrelia burgdorferi or both IFN-g and Borrelia or untreated to investigate immune responses to Lyme disease
Borrelia burgdorferi, the agent of Lyme disease, promotes pro-inflammatory changes in endothelium that lead to the recruitment of leukocytes. The host immune response to infection results in increased levels of IFN-gamma in the serum and lesions of Lyme disease patients that correlate with greater s...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6092 | biostudies-arrayexpress
ProteomicsProteomic Analysis of Lyme Disease: Global Protein Comparison of Three Strains of Borrelia Burgdorferi
We report the proteomic analysis of the archetype B. burgdorferi B31 strain and two other strains (ND40, and JD-1) having different Borrelia pathotypes using strong cation exchange fractionation of proteolytic peptides followed by high-resolution, reversed phase capillary liquid chromatography coupl...
ORGANISM(S): Borreliella Burgdorferi (ncbitaxon:139) 
2020-05-29 | MSV000085503 | MassIVE
ProteomicsIdentification of RNA chaperones by gradient profiling in the Lyme disease spirochete, Borrelia burgdorferi
RNA-binding proteins (RBPs) play key roles in regulating gene expression in bacteria. However, relatively few RBPs have been discovered and characterized in Borrelia (Borreliella) burgdorferi, the causative agent of Lyme disease. We utilized gradient profiling to identify putative RBPs that co-sedim...
ORGANISM(S): Borreliella burgdorferi 
2026-06-29 | PXD068462 | Pride
Lyme disease Borrelia burgdorferi Rna chaperone Rna-binding protein 
TranscriptomicsRNA-seq analysis of PBMCs with TLR1-1805TT and TLR1-1805GG genotypes stimulated and restimulated (innate immune tolerance induction) with B. burgdorferi.
A TLR1 variant (1805GG) associated with severe Lyme disease may drive excessive inflammation. To investigate this, we stimulated (16hr) and restimulated (6hr) PBMCs from donors with or without TLR1-1805GG using Borrelia burgdorferi. Variant carriers showed stronger transcriptional and cytokine respo...
ORGANISM(S): Homo sapiens 
2025-11-13 | E-MTAB-16016 | biostudies-arrayexpress
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