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TranscriptomicsExpression profile of human lymphatic endothelial cells under static or oscillatory shear stress conditions in the presence or absence of FOXC2
Lymphatic valves are specialized units regularly distributed along collecting vessels that allow unidirectional forward propulsion of the lymph, and its efficient transport from tissues to the bloodstream. Lymphatic endothelial cells that cover lymphatic valve sinuses are subjected to complex flow p...
ORGANISM(S): Homo sapiens 
2015-11-09 | E-GEOD-60152 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human intestinal versus dermal lymphatic endothelial cells
In this analysis we have compared the gene expression profiles of lymphatic endothelial cells (LECs) isolated from human intestine (iLECs) versus LECs from human skin (dLECs).
ORGANISM(S): Homo sapiens 
2010-02-03 | E-MEXP-2452 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human lymphatic endothelial cells treated with hepatocyte Growth Factor (HGF)
Effect of Hepatocyte Growth Factor (HGF) on lymphatic endothelial cells.
ORGANISM(S): Homo sapiens 
2005-02-01 | E-MEXP-256 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA sequencing data of zebrafish lymphatic and venous endothelial cells at different developmental stages (36 hpf, 48 hpf, 120 hpf (5 dpf) and 168 hpf (7 dpf))
This dataset contains single-cell RNA sequencing (scRNA-seq) profiles of zebrafish venous and lymphatic endothelial cells across development. Endothelial cells were isolated by FACS from transgenic zebrafish embryos and larvae at 36 hpf, 48 hpf, 5 dpf (120 hpf), and 7 dpf (168 hpf) using endothelial...
ORGANISM(S): Danio rerio 
2026-09-28 | E-MTAB-16797 | biostudies-arrayexpress
TranscriptomicsEvaluation of the effects of shear stress on human dermal microvascular blood and lymphatic endothelial cells
The lymphatic system removes fluid from the interstitial space and returns it to the blood with a tremendous capacity: during inflammation, lymph flow rates can increase dramatically; however, during chronic lymphedema, there is little or no flow. The ability of lymphatic endothelium to sense and ac...
ORGANISM(S): Homo sapiens 
2009-11-30 | E-GEOD-8852 | biostudies-arrayexpress
TranscriptomicsApelin-VEGF-C mRNA delivery as therapeutic for the treatment of secondary lymphedema
Secondary lymphedema (LD) corresponds to a severe lymphatic dysfunction leading to the accumulation of fluid and fibrotic adipose tissue in a limb. Here, we identified apelin (APLN) as a powerful molecule for regenerating lymphatic function in LD. We identified the loss of APLN expression in lymphed...
ORGANISM(S): Homo sapiens 
2023-10-20 | E-MTAB-13381 | biostudies-arrayexpress
ProteomicsQuantitative proteomics of small extracellular vesicles from lymphatic fluid for analyzing the premetastatic niche in melanoma
Melanoma is an aggressive form of skin cancer that often spreads via lymphatic pathways to regional and distant sites. Melanoma-derived lymphatic small extracellular vesicles (sEVs) play a crucial role in forming a tumor-supportive environment for metastasis, or premetastatic niche, within the first...
ORGANISM(S): Homo sapiens (Human) 
2026-01-19 | PXD063898 | Pride
ProteomicsPhosphoproteome Analysis of Cerebrospinal Fluid Extracellular Vesicles in Primary Central Nervous System Lymphoma
Primary central nervous system lymphoma(PCNSL) is a rare extra-nodal non-Hodgkin’s lymphoma and accounts for 3%-4% of central nervous system tumors. Recent studies have highlighted the importance of cerebrospinal fluid derived extracellular vesicles in PCNSL. Extracellular vesicles(EVs) are nanoscal...
ORGANISM(S): Homo Sapiens (human) 
2023-07-12 | PXD040744 | JPOST Repository
TranscriptomicsHuman lymphedema tissues exhibit an inflammatory gene expression profile
Lymphedema (LD) is characterized by the accumulation of protein-rich interstitial fluid, lipids and a significant inflammatory cell infiltrate in the limb. It causes a significant morbidity and is a common disabling disease affecting more than 150 million people worldwide, however there is no yet cu...
ORGANISM(S): Homo sapiens 
2023-06-09 | E-MTAB-13019 | biostudies-arrayexpress
ProteomicsProteomic Profiling of Cerebrospinal Fluid in Adult Rats with Compromised Lymphatic Drainage Using DIA-PASEF
The glymphatic system’s outflow of “dirty” brain fluids collects in the meningeal lymphatic vessels, which drain via lymphatic collectors primarily to the deep cervical lymph nodes (dcLN). It is unclear, however, whether lymphatic dcLN drainage is a prerequisite for normal cerebral homeostasis. Here...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-07-04 | PXD063161 | Pride
Cauterized Rat Dia-pasef 
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