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UnknownExceptional Response to Pembrolizumab for Treatment of Metastatic Chemorefractory Endometrial Carcinoma in a Patient with Lynch Syndrome: A Case Report.
Not available
S-EPMC10134052 | biostudies-literature
TranscriptomicsC9orf72 BAC Transgenic Mice Display Typical Pathologic Features of ALS/FTD
Noncoding expansions of a hexanucleotide repeat (GGGGCC) in the C9orf72 gene are the most common cause of familial amyotrophic lateral sclerosis and frontotemporal dementia. Here we report transgenic mice carrying a bacterial artificial chromosome (BAC) containing the full human C9orf72 gene with ei...
ORGANISM(S): Mus musculus 
2016-02-10 | E-GEOD-77720 | biostudies-arrayexpress
TranscriptomicsInduced pluripotent stem cell models of progranulin-deficient frontotemporal dementia uncover specific reversible neuronal defects.
Multiple FTD patient-specific iPSC lines were generated for the first time, Human neurons of progranulin haploinsufficiency have been established. PGRN S116X neurons are more sensitive to kinase inhibitors-induced cell stress, which can be rescued by ectopic progranulin expression, revealing progran...
ORGANISM(S): Homo sapiens 
2012-10-25 | E-GEOD-40378 | biostudies-arrayexpress
UnknownInteractive enhancer hubs (iHUBs) mediate transcriptional reprogramming and adaptive resistance in pancreatic cancer.
Not available
S-EPMC10402638 | biostudies-literature
UnknownFentanyl overdose: Temporal effects and prognostic factors in SKH1 mice.
Not available
S-EPMC10939806 | biostudies-literature
UnknownAn application of matching algorithms to generalize small-area estimates of chronic pain prevalence to neighbourhoods across England.
Not available
S-EPMC12123305 | biostudies-literature
UnknownEPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation.
Not available
S-EPMC2529053 | biostudies-literature
GenomicsCRUK-ICGC Prostate Cancer Group Study
Prostate cancer somatic genomic sequencing data generated from 2011 onwards under auspices of the International Cancer Genome Consortium Prostate Cancer UK consortium (CRUK-ICGC Prostate Group), co-led by Colin Cooper and Ros Eeles, with other Principal Investigators (Brewer, Neal, Bova, McDermott, ...
EGAS00001000262 | EGA
UnknownProcessive Recoding and Metazoan Evolution of Selenoprotein P: Up to 132 UGAs in Molluscs.
Not available
S-EPMC6885538 | biostudies-literature
TranscriptomicsProgranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation
Microglia repair injury and maintain homeostasis in the brain, but whether aberrant microglial activation can contribute to neurodegeneration remains unclear. Here, we use transcriptome profiling to demonstrate that deficiency in frontotemporal dementia (FTD) gene progranulin (Grn) leads to an age-d...
ORGANISM(S): Mus musculus 
2016-03-31 | E-GEOD-75083 | biostudies-arrayexpress
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