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TranscriptomicsA Phase Two Randomised Controlled Trial of Belimumab in Kidney Transplant Recipients Demonstrates Comparable Safety, a Reduction in De Novo Antibody Production and an Increase in Regulatory B Cells.
There is an urgent unmet need in solid organ transplantation for immunotherapeutic strategies that target B cells and plasma cells, ideally without increasing infectious complications. We conducted a phase 2 double-blind randomised placebo-controlled trial to assess the safety and potential efficacy...
ORGANISM(S): Homo sapiens 
2018-06-11 | E-MTAB-5906 | biostudies-arrayexpress
UnknownCrosstalk between vrille transcripts, proteins, and regulatory elements controlling circadian rhythms and development in Drosophila.
Not available
S-EPMC7753146 | biostudies-literature
UnknownEarly Versus Delayed Initiation of Concurrent Palliative Oncology Care: Patient Outcomes in the ENABLE III Randomized Controlled Trial.
Not available
S-EPMC4404422 | biostudies-literature
TranscriptomicsAlterations to hormone regulated defense and stress response networks contribute to the greater growth of Arabidopsis F1 hybrids
Heterosis, or hybrid vigor, has been exploited in agriculture to deliver increases in crop yields for over a century, yet the molecular basis is not well understood We have studied the transcriptomes of 15 day old seedlings from intraspecific Arabidopsis hybrids with varying levels of heterosis and...
ORGANISM(S): Arabidopsis thaliana 
2015-10-01 | E-GEOD-64475 | biostudies-arrayexpress
UnknownBenefits of Early Versus Delayed Palliative Care to Informal Family Caregivers of Patients With Advanced Cancer: Outcomes From the ENABLE III Randomized Controlled Trial.
Not available
S-EPMC4404423 | biostudies-literature
UnknownBiochemical and genetic analysis of Ecm14, a conserved fungal pseudopeptidase.
Not available
S-EPMC7706225 | biostudies-literature
TranscriptomicsCoordinated regulation of synthesis and stability of RNA during the acute TNF-induced proinflammatory response
Steady-state gene expression is a coordination of synthesis and decay of RNA through epigenetic regulation, transcription factors, miRNAs, and RNA-binding proteins. Here, we present Bru-Seq and BruChase-Seq to assess genome-wide changes to RNA synthesis and stability in human fibroblasts at homeosta...
ORGANISM(S): Homo sapiens 
2013-01-29 | E-GEOD-43440 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of CD14 monocytyes and CD16 neutrophils from patients with systemic lupus erythematosus
Copy number variation (CNV) has been shown to be common in regions of the genome coding for immune-related genes, and thus impacts upon polygenic autoimmunity. Low copy number of FCGR3B has recently been associated with systemic lupus erythematosus (SLE). FcγRIIIb is a glycosylphosphatidylino...
ORGANISM(S): Homo sapiens 
2008-10-02 | E-TABM-463 | biostudies-arrayexpress
TranscriptomicsAT13148 is a novel, oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity
Purpose: Deregulated phosphatidylinositol 3-kinase pathway signaling through AGC kinases including AKT, p70S6 kinase, PKA, SGK and Rho kinase, is a key driver of multiple cancers. The simultaneous inhibition of multiple AGC kinases may increase antitumor activity and minimize clinical resistance com...
ORGANISM(S): Homo sapiens 
2012-07-19 | E-GEOD-38008 | biostudies-arrayexpress
UnknownmiRNA profiling of human naive CD4 T cells links miR-34c-5p to cell activation and HIV replication.
Not available
S-EPMC5286376 | biostudies-literature
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