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GenomicsGATA4 represses an ileal program of gene expression in the proximal small intestine by inhibiting the acetylation of histone H3, lysine 27.
GATA4 is expressed in the proximal 85% of small intestine where it promotes a proximal intestinal ('jejunal') identity while repressing a distal intestinal ('ileal') identity, but its molecular mechanisms are unclear. Here, we tested the hypothesis that GATA4 promotes a jejunal versus ileal identity...
ORGANISM(S): Mus musculus 
2015-05-16 | E-GEOD-68957 | biostudies-arrayexpress
GenomicsLoss of PHF20 does not negatively affect deposition of H4K16 acetylation, but does impact the expression of MOF targets
Protein post-translational modifications transmit signals in part by creating binding sites for effector molecules. This is especially true in epigenetic pathways where histone tails are heavily modified, resulting in the recruitment of molecules that can affect transcription. One such molecule, pla...
ORGANISM(S): Mus musculus 
2012-02-27 | E-GEOD-29306 | biostudies-arrayexpress
ProteomicsHaloferax volcanii lysine acetylation
Oxidative stress adaptation strategies are important to cell function and are linked to cardiac, neurodegenerative disease and cancer. Representatives of the domain Archaea are used as model organisms based on their extreme tolerance to oxidants and close evolutionary relationship with eukaryotes. S...
ORGANISM(S): Haloferax volcanii DS2 
2023-07-20 | PXD041799 | Pride
Ptms Halophiles Acetylation Haloferax volcanii Oxidative stress 
ProteomicsTargeted degradation of the enhancer lysine acetyltransferases CBP and p300
The enhancer factors CBP/p300 maintain gene expression programs through lysine acetylation of chromatin and transcriptional regulators and by scaffolding functions mediated by several protein-protein interaction domains. We have designed dCBP-1, a compound that induces degradation of CBP/p300, and ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-11-15 | MSV000086457 | MassIVE
ProteomicsSystematic analysis of the lysine acetylome reveals diverse functions of lysine acetylation in the oleaginous yeast Yarrowia lipolytica
Lysine acetylation of proteins, a major post-translational modification, plays a critical regulatory role in almost every aspects in both eukaryotes and prokaryotes. Yarrowia lipolytica, an oleaginous yeast, is considered as a model for bio-oil production due to its ability to accumulate a large amo...
ORGANISM(S): Yarrowia lipolytica (Candida lipolytica) 
2018-11-22 | PXD006272 | Pride
Yarrowia lipolytica Oleaginous yeast Acetylproteome Lipid biosynthesis Lysine acetylation 
GenomicsA histone acetylation switch regulates H2A.Z deposition by the SWR-C remodeling enzyme
The histone variant H2A.Z plays key roles in gene expression, DNA repair, and centromere function. H2A.Z deposition is controlled by SWR-C chromatin remodeling enzymes that catalyze the nucleosomal exchange of canonical H2A with H2A.Z. Here we report that acetylation of histone H3 lysine 56 (H3-K56A...
ORGANISM(S): Saccharomyces cerevisiae W303 
2013-04-15 | E-GEOD-43935 | biostudies-arrayexpress
ProteomicsCrosstalk of Protein Expression and Lysine Acetylation in Response to TMV Infection in Nicotiana benthamiana
Kac, a reversible PTM, plays essential roles in various biological processes, including those involving metabolic pathways, pathogen resistance and transcription, in both prokaryotes and eukaryotes. TMV, the major factor that causes poor quality of Solanaceae crops worldwide, directly alters many me...
ORGANISM(S): Nicotiana tabacum (Common tobacco) 
2022-10-15 | PXD035737 | Pride
Lysine acetylation Tmv Nicotiana benthamiana Proteome 
ProteomicsProteomic Quantification of Lysine Acetylation in mouse hippocampus
Major depressive disorder (MDD) is a leading cause of disability around the world and contributes greatly to the global burden of disease. Mounting evidence suggests that gut microbiota dysbiosis may be involved in the pathophysiology of MDD through the microbiota–gut–brain axis. Recent research sug...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-09 | PXD022577 | Pride
Lysine acetylation Specific pathogen-free Depression Gut microbiota Germ-free 
ProteomicsAcetyl-proteome profiling of Staphylococcus aureus revealed lysine acetylation in bacterial antibiotic resistance
Protein post-translational modifications (PTMs) play crucial roles in various biological processes across prokaryotes and eukaryotes. Lysine acetylation (Kac), which is observed in different bacteria species and is known to be a dynamic and reversible PTM involved in numerous physiological functions...
ORGANISM(S): Staphylococcus aureus 
2024-10-17 | PXD043277 | Pride
Post-translational modification  staphylococcus aureus  antibiotic resistance  lysine acetylation  ribosome 
ProteomicsFirst proteomic analysis of lysine acetylation on extensive functions in Solenopsis invicta Buren
Lysine acetylation (Kac) plays a critical role in the regulation of a great deal of important cellular processes. However, little is known about Kac in Solenopsis invicta, which is one of the 100 most dangerous invasive species in the world. Lysine acetylome in S. invicta was evaluated for the first...
ORGANISM(S): Solenopsis invicta 
2020-12-02 | PXD019033 | Pride
Lysine acetylation solenopsis invicta subcellular localization enrichment 
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