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ProteomicsFirst Global Proteomic Analysis of Lysine Malonylation in Toxoplasma gondii
Lysine malonylation (Kmal) is a new posttranslational modification (PTM), which has been reported in several prokaryotic and eukaryotic species. Although Kmal can regulate many and diverse biological processes in various organisms, knowledge about this important PTM in the apicomplexan parasite Toxo...
ORGANISM(S): Toxoplasma gondii 
2020-05-27 | PXD015809 | Pride
Post-translational  modifications Toxoplasma gondii Malonylome Lysine malonylation 
ProteomicsNOVEL ROLE OF FATTY ACID SYNTHASE IN ANGIOGENESIS THROUGH MODULATION OF LYSINE MALONYLATION OF MTOR
The role of fatty acid synthesis (FAS) in endothelial cells (ECs) remains incompletely characterized. In this project, we found that silencing of fatty acid synthase (FASN) impedes vessel sprouting by reducing EC proliferation. Moreover, loss of FASN in ECs impaired angiogenesis in vivo, and FASN bl...
ORGANISM(S): Homo sapiens (Human) 
2019-07-08 | PXD006503 | Pride
Protein malonylation Fatty acid synthesis Endothelial cell metabolism 
ProteomicsSystematic analysis of lysine malonylation in Streptococcus mutans
Lysine malonylation is an evolutionarily conserved PTM from bacteria to mammals and involves malonyl-coenzyme (CoA) as a cofactor. Since the malonyl group has an acidic carboxylic group under physiological pH, malonylated lysine is negatively charged, which might impact on protein function and enzym...
ORGANISM(S): Streptococcus mutans UA159 
2022-11-17 | PXD038045 | Pride
Malonylation Biofilm Post-translational modification Streptococcus mutans 
UnknownSystematic analysis of lysine malonylation in Streptococcus mutans.
Not available
S-EPMC9742479 | biostudies-literature
UnknownProteomic and Biochemical Studies of Lysine Malonylation Suggest Its Malonic Aciduria-associated Regulatory Role in Mitochondrial Function and Fatty Acid Oxidation.
Not available
S-EPMC4638046 | biostudies-literature
UnknownGlobal Proteomic Analysis of Lysine Malonylation in Toxoplasma gondii.
Not available
S-EPMC7198775 | biostudies-literature
ProteomicsComparative Analysis Reveals Genotype-specific Lyisne Malonylation of Toxoplasma gondii
Toxoplasma gondii is a protozoan parasite which can infect a wide range of animals, including humans. According to virulence, it is generally divided into three different strains, namely type I (RH strain), type II (PRU strain) and type III (VEG strain). Lysine malonylation (Kmal) is a new type of p...
ORGANISM(S): Toxoplasma gondii VEG 
2022-05-11 | PXD029366 | Pride
Toxoplasma gondii Differentially expressed proteins (deps) Lysine malonylation Genotype 
ProteomicsQuantitative Analysis of Lysine Malonylation Proteome Unravels Physiological and Biochemical Mechanism in Responding to Salicylic Acid in Roots of Platycodon grandiflorus
Salicylic acid, as a plant hormone, significantly affects physiological and biochemical indexes of such as soluble sugar, malondialdehyde content, peroxidase and superoxide dismutase enzyme activity in Platycodon grandiflorus. Lysine malonylation is a post-translational modification that involves va...
ORGANISM(S): Platycodon grandiflorus 
2025-05-07 | PXD058676 | Pride
Platycodon grandiflorus  salicylic acid  lysine malonylation  medicinal plants  qualitative proteome  post-translational modification. 
UnknownThe Enzyme Lysine Malonylation of Calvin Cycle and Gluconeogenesis Regulated Glycometabolism in Nostoc flagelliforme to Adapt to Drought Stress.
Not available
S-EPMC10179182 | biostudies-literature
ProteomicsIntegrated proteome and malonylome analyses reveal the potential meaning of TLN1 and ACTB in end-stage renal disease
Purpose: End-stage renal disease (ESRD) is a condition that is characterized by the loss of kidney function. ESRD patients suffer from various endothelial dysfunctions, inflammation, and immune system defects. Lysine malonylation (Kmal) is a recently discovered post-translational modification (PTM)....
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD035147 | Pride
Lysine malonylation (kmal) Platelet activation Post-translational modification (ptm) End-stage renal disease (esrd) Chronic kidney disease (ckd) 
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