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MetabolomicsTFAM loss induces nuclear actin assembly upon mDia2 malonylation to promote liver cancer metastasis
The mechanisms underlying cancer metastasis remain poorly understood. Here, we report that TFAM deficiency rapidly and stably induced spontaneous lung metastasis in mice with liver cancer. Interestingly, unexpected polymerization of nuclear actin was observed in TFAM-knockdown HCC cells when cytoske...
2022-06-23 | MTBLS4307 | MetaboLights
ProteomicsMalonylation of Nucleolin Promotes Cell Proliferation in Hepatocarcinoma cells by enhancing AKT translation
Cancer cells undergo metabolic reprogramming that is intricately linked to malignancy. Protein acylation is especially responsive to metabolic changes, influencing signal transduction pathways and fostering cell proliferation. However, the role of malonylation in cancer remains poorly understood. In...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD048727 | Pride
Malonylation cancer hepatocellular 
ProteomicsMalonylation of Acetyl-CoA Carboxylase 1 Promotes Hepatic Steatosis and Is Attenuated by Ketogenic Diet in NAFLD
Protein post-translational modifications (PTMs) participate in important bioactive regulatory processes and therefore can help elucidate the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Here, we investigate the involvement of PTMs in ketogenic diet (KD)-improved fatty liver by multi-om...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-21 | PXD040481 | Pride
Lysine malonylation  hepatic steatosis  acetyl-coa carboxylase 1  ketogenic diet. 
ProteomicsNOVEL ROLE OF FATTY ACID SYNTHASE IN ANGIOGENESIS THROUGH MODULATION OF LYSINE MALONYLATION OF MTOR
The role of fatty acid synthesis (FAS) in endothelial cells (ECs) remains incompletely characterized. In this project, we found that silencing of fatty acid synthase (FASN) impedes vessel sprouting by reducing EC proliferation. Moreover, loss of FASN in ECs impaired angiogenesis in vivo, and FASN bl...
ORGANISM(S): Homo sapiens (Human) 
2019-07-08 | PXD006503 | Pride
Protein malonylation Fatty acid synthesis Endothelial cell metabolism 
ProteomicsFirst Global Proteomic Analysis of Lysine Malonylation in Toxoplasma gondii
Lysine malonylation (Kmal) is a new posttranslational modification (PTM), which has been reported in several prokaryotic and eukaryotic species. Although Kmal can regulate many and diverse biological processes in various organisms, knowledge about this important PTM in the apicomplexan parasite Toxo...
ORGANISM(S): Toxoplasma gondii 
2020-05-27 | PXD015809 | Pride
Post-translational  modifications Toxoplasma gondii Malonylome Lysine malonylation 
ProteomicsLysine crotonylation, 2-hydroxyisobutyrylation, acetylation, and malonylation profiles in OSCC.
Liquid chromatography-tandem mass spectrometry (LC‒MS/MS) analysis was performed for lysine crotonylation (KCr), 2-hydroxyisobutyrylation (Khib), acetylation (Kac), and malonylation (Kma) to obtain a comprehensive profile and reveal the differences in modified proteins between OSCC and adjacent tiss...
ORGANISM(S): Homo sapiens (Human) 
2026-09-21 | PXD073784 | Pride
Oral squamous cell carcinoma  lysine 2-hydroxyisobutyrylation  lysine crotonylation  lysine acetylation  lysine malonylation 
ProteomicsComparative Analysis Reveals Genotype-specific Lyisne Malonylation of Toxoplasma gondii
Toxoplasma gondii is a protozoan parasite which can infect a wide range of animals, including humans. According to virulence, it is generally divided into three different strains, namely type I (RH strain), type II (PRU strain) and type III (VEG strain). Lysine malonylation (Kmal) is a new type of p...
ORGANISM(S): Toxoplasma gondii VEG 
2022-05-11 | PXD029366 | Pride
Toxoplasma gondii Differentially expressed proteins (deps) Lysine malonylation Genotype 
TranscriptomicsMalonylation of Acetyl-CoA Carboxylase 1 Promotes Hepatic Steatosis and Is Attenuated by Ketogenic Diet in NAFLD
Protein post-translational modifications (PTMs) participate in important bioactive regulatory processes and therefore can help elucidate the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Here, we investigate the involvement of PTMs in ketogenic diet (KD)-improved fatty liver by multi-om...
ORGANISM(S): Mus musculus 
2023-03-05 | GSE226139 | GEO
UnknownMal-Prec: computational prediction of protein Malonylation sites via machine learning based feature integration : Malonylation site prediction.
Not available
S-EPMC7682087 | biostudies-literature
ProteomicsMass spectrometric profiling of lysine malonylation in CRISPRi 562 cells lines to investigate malonylation activity of lysine acetyltransferases
Lysine malonylation is a protein posttranslational modification with potentially broad biological impact. We present a protocol to generate stable gene knockdown K562 cell lines through lentiviral infection of a CRISPRi system followed by lysine malonylation measurement using mass spectrometry (MS)....
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-12-04 | MSV000093564 | MassIVE
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