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TranscriptomicsGene profile of Myeloid derived Suppressive Cells from the Bone Marrow of Lysosomal Acid Lipase Knock-out Mice
Expression profile of MDSC isolated from Bone marrow of lysosomal acid Lipase mice compared to the WT counterpart four samples
ORGANISM(S): Mus musculus 
2012-03-06 | E-GEOD-29401 | biostudies-arrayexpress
ProteomicsPronounced metabolic alterations and susceptibility to inflammation, fibrosis, and cancer in livers from lysosomal acid lipase-deficient mice
Lysosomal acid lipase (LAL) is the sole lysosomal enzyme responsible for the degradation of cholesteryl esters and triacylglycerols at acidic pH. Impaired LAL activity leads to LAL deficiency (LAL-D), a severe and fatal disease characterized by ectopic lysosomal lipid accumulation. Reduced LAL activ...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-24 | PXD042478 | Pride
Lysosomal acid lipase (lal) Lal deficiency Liver Mouse Non-alcoholic fatty liver disease (nafld) 
GenomicsANGPTL4 suppress clear cell renal cell carcinoma via inhibition lysosomal acid lipase
ANGPTL4 suppress clear cell renal cell carcinoma via inhibition lysosomal acid lipase
PRJNA1140650 | ENA
GenomicsHepatic Lysosomal Acid Lipase Overexpression Worsens Hepatic Inflammation in Mice Fed a Western Diet
Hepatic Lysosomal Acid Lipase Overexpression Worsens Hepatic Inflammation in Mice Fed a Western Diet
PRJNA748030 | ENA
GenomicsRescue of lysosomal acid lipase deficiency in mice by AAV liver gene transfer
Rescue of lysosomal acid lipase deficiency in mice by AAV liver gene transfer
PRJNA1062373 | ENA
ProteomicsOff-target effects of the lysosomal acid lipase inhibitors Lalistat-1 and Lalistat-2 on neutral lipid hydrolases
Lysosomal acid lipase (LAL) is the key enzyme of lysosomal lipid hydrolysis, which degrades cholesteryl esters (CE), triacylglycerols (TG), diacylglycerols (DG), and retinyl esters. The role of LAL in various cellular processes has mostly been studied in LAL-deficient (Lal-/-) mice, which share phen...
ORGANISM(S): Mus musculus (Mouse) 
2022-05-13 | PXD030672 | Pride
Lal  lipolysis  lipid hydrolase activity  atgl  hsl  mgl 
TranscriptomicsGene profile of Myeloid derived Suppressive Cells from the Bone Marrow of Lysosomal Acid Lipase Knock-out Mice
Expression profile of MDSC isolated from Bone marrow of lysosomal acid Lipase mice compared to the WT counterpart
ORGANISM(S): Mus musculus 
2012-03-06 | GSE29401 | GEO
MetabolomicsNitrate-Sialin2 Axis Couples ER-Mitochondrial Calcium Signaling with Fatty Acid Metabolism to Drive White Adipose Browning
Nutrient cues shape adipose homeostasis; however, the mechanism by which inorganic signals engage organelle networks to drive white fat browning remains unclear. Here, we identify a nitrate-Sialin2 pathway that converts dietary nitrate into a spatially confined thermogenic program. Sialin2 localizes...
2026-05-17 | MTBLS14192 | MetaboLights
TranscriptomicsANGPTL4 suppress clear cell renal cell carcinoma via inhibition lysosomal acid lipase
Renal cell carcinoma (RCC), the most common form of kidney cancer, is a heterogeneous disease with clear cell RCC (ccRCC) being the most prevalent and aggressive subtype. While most ccRCC tumors have elevated expression of angiopoietin-like 4 (ANGPTL4), in our study we identified a significant subse...
ORGANISM(S): Homo sapiens 
2024-07-30 | GSE273236 | GEO
UnknownLysosomal Acid Lipase in Lipid Metabolism and Beyond.
Not available
S-EPMC6482091 | biostudies-literature
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