Lysosomal cholesterol accumulation

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Lab affiliation

Team SOAP, CRCI2NA, Nantes Université, Inserm, CNRS, Université d’Angers, Nantes, France (2)
1- i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Portugal 2- IBMC - Instituto de Biologia Celular e Molecular, Universidade do Porto, Portugal 3- ICBAS - Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Portugal (1)
3Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Padualaan 8, Utrecht 3584 CH, The Netherlands. 4Netherlands Proteomics Center, Padualaan 8, Utrecht 3584 CH, The Netherlands. (1)
Calico Life Sciences (1)
DZNE Munich, Neuroproteomics, Feodor-Lynen Str. 17, 81377 Munich, Germany (1)
DZNE Munich, Neuroproteomics, Feodor-Lynen-Str. 17, 81377 München, Germany (1)
Department of Biology University of Copenhagen Denmark (1)
Department of Brain Sciences, Daegu Gyeongbuk Institute of Science & Technology (1)
Department of Cell and Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA-92037 (1)
Discovery Proteomics Facility University of Oxford (1)
Faculty of Technical Chemistry, Institute of Chemical Technologies and Analytics, Technische Universität Wien (TU Wien), 1060 Vienna, Austria; Diagnostic and Research Institute of Pathology, Medical University of Graz, 8010 Graz, Austria; BiotechMed-Graz, 8010 Graz, Austria; (1)
Molecular Biology and Biochemistry, Medical University of Graz (1)
Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark (1)
Pacific Northwest National Laboratory (1)
The Scripps Research Institute (1)
University of Potsdam Institute of Nutritional Science Cellular Physiology of Nutrition Karl-Liebknecht-Str. 24/25 Building 29, Room 0.08 14476 Potsdam, Germany, EU (1)

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Cholesterol maintains the degradative capacity of lysosomes during clearance and recycling of dysfunctional mitochondria

Efficient clearance and recycling of dysfunctional mitochondria through the robust catabolic activity of lysosomes is essential for cellular health. However, how membrane lipids contribute to maintaining the degradative capacity of lysosomes remains poorly understood. Here, we show that cholesterol ...

2026-07-30 | MTBLS15181 | MetaboLights

ApoE4-dependent lysosomal cholesterol accumulation impairs mitochondrial homeostasis and oxidative phosphorylation in human astrocytes

Recent developments in genome sequencing have expanded the knowledge of genetic factors associated with late-onset Alzheimer’s disease (AD). Among them, genetic variant e4 of the APOE gene (ApoE4) confers the greatest disease risk. Dysregulated glucose metabolism is an early pathological feature of ...

ORGANISM(S): Homo sapiens (Human)

2023-09-12 | PXD045298 | Pride

Use of BODIPY-Cholesterol (TF-Chol) for Visualizing Lysosomal Cholesterol Accumulation.

Not available

S-EPMC4988379 | biostudies-literature

HR3/RORα-mediated cholesterol sensing regulates TOR signaling

Cells and organisms adjust their growth based on the availability of cholesterol, which is essential for cellular functions. However, the mechanisms by which cells sense cholesterol levels and translate these into growth signals are not fully understood. We report that cholesterol rapidly activates ...

ORGANISM(S): Homo sapiens (Human) Drosophila melanogaster (Fruit fly)

2026-02-10 | PXD074014 | Pride

Lysosomal damage due to cholesterol accumulation triggers immunogenic cell death.

Not available

S-EPMC12013445 | biostudies-literature

Lysosomal cholesterol accumulation contributes to the movement phenotypes associated with NUS1 haploinsufficiency.

Not available

S-EPMC8263489 | biostudies-literature

Lysosomal cholesterol accumulation in macrophages leading to coronary atherosclerosis in CD38(-/-) mice.

Not available

S-EPMC4882979 | biostudies-literature

Lysosomal cholesterol accumulation inhibits subsequent hydrolysis of lipoprotein cholesteryl ester.