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ProteomicsMembrane atg8ylation coordinates stress granule formation and mTOR inactivation in response to lysosomal damage
We report that lysosomal damage is a hitherto unknown inducer of stress granule (SG) formation and that the process termed membrane atg8ylation coordinates SG formation with mTOR inactivation during lysosomal stress. SGs were induced by lysosome-damaging agents including SARS-CoV-2ORF3a, Mycobacteri...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-06-09 | MSV000089622 | MassIVE
ProteomicsAtg8ylation coordinates stress granule formation and mTOR inactivation in response to lysosomal damage
Stress granule formation is a part of cellular homeostatic responses, with prototypical inducers being viral infections, heat shock and oxidative damage. Here we show that lysosomal damage is a previously unappreciated robust inducer of stress granule formation interlinked with mTOR inactivation dur...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000088152 | MassIVE
ProteomicsProteins enriched on damaged lysosomes in 293T
Lysosomal membrane permeabilization (LMP) or lysosomal membrane damage is commonly associated with aging and age-related diseases. In searching for cellular mechanisms in response to LMP, we used a proteomic approach to identify proteins enriched on damaged lysosomes. This unbiased approach identifi...
ORGANISM(S): Homo sapiens (Human) 
2022-09-07 | PXD028852 | Pride
Human Lysosomal membrane permeabilization 
MetabolomicsShotgun lipidomics of HeLa whole-cell lysates and lysosomes following LLOMe treatment

Perturbations in lysosome integrity are tightly linked to neurological disorders and ageing, but the underlying pathogenic mechanisms are incompletely understood. Using an unbiased proteomic approach, we here identified the bridge-like lipid transport protein VPS13C/PARK23 as a key component of a...

2026-07-03 | MTBLS14737 | MetaboLights
ProteomicsLysosomal retargeting of Myoferlin mitigates membrane stress to enable pancreatic cancer growth
Lysosomes were immuno-isolated from HEK293T cells and PaTu8988T pancreatic ductal adenocarcinoma cells and analyzed by mass spectrometry based proteomics. Three independent biological replicates for each cell line is provided.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-01-26 | MSV000086769 | MassIVE
ProteomicsA Lysosome membrane regeneration pathway depends on TBC1D15 and autophagic lysosomal reformation proteins
Acute lysosomal membrane damage reduces the cellular population of functional lysosomes. However, these damaged lysosomes have a remarkable recovery potential independent of lysosomal biogenesis and remain unaffected in TFEB/TFE3-depleted cells. We combined proximity labelling based proteomics, bioc...
ORGANISM(S): Homo sapiens (Human) 
2023-03-07 | PXD040191 | Pride
Autophagy Lysosomal regeneration Lysosomes Autophagic lysosomal reformation Tbc family of proteins 
UnknownRestoration of lysosomal function after damage is accompanied by recycling of lysosomal membrane proteins.
Not available
S-EPMC7224388 | biostudies-literature
GenomicsMitochondrial Protein Import Stress Causes Lysosomal Damage and Tissue Atrophy
Mitochondrial Protein Import Stress Causes Lysosomal Damage and Tissue Atrophy
PRJNA1188003 | ENA
GenomicsThe antibacterial factor APOL3 couples lysosomal damage to mitochondrial DNA efflux and type I IFN induction
The antibacterial factor APOL3 couples lysosomal damage to mitochondrial DNA efflux and type I IFN induction
PRJNA1375674 | ENA
UnknownMonitoring and assessment of lysosomal membrane damage in cultured cells using the high-content imager.
Not available
S-EPMC10148077 | biostudies-literature
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