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ProteomicsLysyl hydroxylase 3 mediated post-translational modifications are required for proper biosynthesis of collagen a1a1a2(IV)
We performed proteomic identification of type IV collagen gel bands from wild-type and lysyl hydroxylase 3 knockout cells by LC-MS after trypsin digestion.
ORGANISM(S): Mus Musculus (mouse) 
2022-11-21 | PXD035051 | JPOST Repository
ProteomicsAnalysis of proline and lysine post-translational modifications of collagen from prolyl 3-hydroxylase 3 and lysyl hydroxylase 1 null mice
We performed shotgun proteomic analysis of type V collagens purified from wild-type mice and prolyl 3-hydroxylase 3 or lysyl hydroxylase 1 null mice by LC-MS after trypsin digestion for identification of lysine glycosylation sites.
ORGANISM(S): Mus Musculus (mouse) 
2021-02-19 | PXD019748 | JPOST Repository
TranscriptomicsGene expression profiling of metastatic lung cancer cell lines
During malignant disease progression, the extracellular matrix (ECM) of epithelial tumors accumulates inter-molecular cross-links between collagen strands; these cross-links enhance ECM stiffness and trigger tumor cell invasion and dissemination, but the mechanisms that regulate intra-tumoral collag...
ORGANISM(S): Mus musculus 
2015-03-12 | E-GEOD-49315 | biostudies-arrayexpress
GenomicsLysyl hydroxylase 2 deficiency promotes filopodia formation and fibroblast migration
Lysyl hydroxylase 2 deficiency promotes filopodia formation and fibroblast migration
PRJNA772615 | ENA
UnknownCloning and characterization of a third human lysyl hydroxylase isoform.
Not available
S-EPMC27920 | biostudies-literature
TranscriptomicsLysyl hydroxylase 2 deficiency promotes filopodia formation and fibroblast migration
Lysyl hydroxylase 2 (LH2) regulates the intermolecular cross-linking of collagen molecules. Accumulation of LH2-modified collagen, which is highly stable and resistant to collagenase cleavage, is one of the causes of fibrosis. In this study, we established LH2-deficient fibroblasts and first analyze...
ORGANISM(S): Mus musculus 
2021-10-20 | GSE186100 | GEO
UnknownGenomic structure and embryonic expression of zebrafish lysyl hydroxylase 1 and lysyl hydroxylase 2.
Not available
S-EPMC1828209 | biostudies-literature
TranscriptomicsLysyl hydroxylase 1 deficiency exacerbates the alterations of gene transcriptional profile of abdominal aorta in angiotensin II induced abdominal aortic aneurysm
Lysyl hydroxylase 1 (LH1) plays an important role in hydroxylation of lysyl residuel in Xaa-Lys-Gly. The hydroxylysine residues serve as sites of attachment for carbohydrate units which are essential for the formation of intra- and intermolecular collagen crosslinks. To gain mechanistic insights int...
ORGANISM(S): Mus musculus 
2021-08-15 | GSE175683 | GEO
UnknownA connective tissue disorder caused by mutations of the lysyl hydroxylase 3 gene.
Not available
S-EPMC2561927 | biostudies-literature
UnknownMolecular architecture of the multifunctional collagen lysyl hydroxylase and glycosyltransferase LH3.
Not available
S-EPMC6082870 | biostudies-literature
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