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ProteomicsTumour mtDNA mutations drive aerobic glycolysis to enhance checkpoint blockade (part 2)
Mitochondrial DNA (mtDNA) encodes essential machinery for respiration and metabolic homeostasis but is paradoxically among the most common targets of somatic mutations in the cancer genome, with truncating mutations in complex I genes being over-represented1 . While mtDNA mutations have been associ...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-08 | PXD044987 | Pride
Melanoma Cancer Complex i Mitochondrial dna 
TranscriptomicsTranscriptomics analysis of skeletal muscle in humans with heart failure
Heart failure is a multisystem syndrome caused by structural and functional defects in multiple tissues. The study aims to identify differentially regulated genes in skeletal muscle of heart failure patients. Here, we obtained biopsies from the pectoralis major muscle and performed RNA sequencing to...
ORGANISM(S): Homo sapiens 
2020-09-07 | E-MTAB-8531 | biostudies-arrayexpress
TranscriptomicsGENOMIC ANALYSIS OF FIBROLAMELLAR HEPATOCELLULAR CARCINOMA REVEALS A UNIQUE MOLECULAR PROFILE
Fibrolamellar hepatocellular carcinoma (FLC) is a rare primary hepatic cancer usually developed in non-cirrhotic livers of children and young adults with unknown etiology. Treatment is limited to surgical intervention. To date, molecular pathogenesis of FLC has been poorly characterized. A cohort of...
ORGANISM(S): Homo sapiens 
2015-02-12 | E-GEOD-59443 | biostudies-arrayexpress
UnknownHigh Frequency and Poor Outcome of Philadelphia Chromosome-Like Acute Lymphoblastic Leukemia in Adults.
Not available
S-EPMC5455698 | biostudies-literature
MetabolomicsTowards improving point-of-care diagnosis of non-malaria febrile illness: a metabolomics approach
Background: Non-malaria febrile illnesses such as bacterial bloodstream infections (BSI) are a leading cause of disease and mortality in the tropics. However, there are no reliable, simple diagnostic tests for identifying BSI or other severe non-malaria febrile illnesses. We hypothesized that differ...
2016-03-17 | MTBLS315 | MetaboLights
UnknownImpact of centre volume, surgeon volume, surgeon experience and geographic location on reoperation after intramedullary nailing of tibial shaft fractures
Not available
S-EPMC8410470 | biostudies-literature
TranscriptomicsMolecular phenotyping of multiple mouse strains under metabolic challenge uncovers Elovl2 as a novel regulator of glucose-induced insulin secretion
Defective insulin secretion by pancreatic β cells underlies the development of type 2 diabetes (T2D). High fat diet-fed mice are commonly used to study diabetes progression, but studies are usually limited to a single strain, such as C57Bl/6J. Here, we use a systems biology approach to integrate la...
ORGANISM(S): Mus musculus 
2017-04-28 | E-GEOD-78183 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human SCLC cell line set 2
RNA expression analysis was performed to compare patterns to sensitivity to BCL2 inhibitors (ABT-263). Overexpression of the prosurvival Bcl-2 family members (Bcl-2, Bcl-xL and Mcl-1) is commonly associated with tumor maintenance, progression and chemoresistance. We previously reported the discover...
ORGANISM(S): Homo sapiens 
2008-06-19 | E-GEOD-10841 | biostudies-arrayexpress
GenomicsGenomic Sequencing of Medulloblastoma

Medulloblastomas are the most common malignant brain tumors in children. Identifying and understanding the genetic events that drive these tumors is critical for the development of more effective diagnostic, prognostic and therapeutic strategies. Recently, our group and others described distinct ...

phs000504.v1.p1 | EGA
GenomicsPCGP Ph-like ALL
Background: BCR-ABL1-like, or Ph-like acute lymphoblastic leukemia is characterized by a gene expression profile similar to BCR-ABL1 positive ALL, genetic alterations of lymphoid transcription factor genes, and poor outcome. Sequencing of small numbers of Ph-like ALL cases has identified genetic alt...
EGAS00001000654 | EGA
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