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ProteomicsIgG M-protein quantification by PRM in blood of multiple myeloma patient
The amino acid sequence of the M-protein for multiple myeloma is unique compared to the polyclonal antibodies in patients’ blood. This uniqueness is exploited to develop an ultra-sensitive M-protein detection method utilizing mass spectrometry (MS). The method involves the de novo amino acid sequenc...
ORGANISM(S): Homo Sapiens 
2021-07-26 | PXD022980 | panorama
ProteomicsIntegrating serum protein electrophoresis with mass spectrometry, a new workflow for M-protein detection and quantification
Serum protein electrophoresis (SPE) and immunofixation electrophoresis (IFE) are standard tools for multiple myeloma (MM) routine diagnostics. M-protein is a biomarker for MM that can be quantified with SPE and characterized with IFE. We have investigated combining SPE/IFE with targeted mass spectro...
ORGANISM(S): Homo sapiens (Human) 
2020-01-07 | PXD016325 | Pride
Serum protein electrophoresis Immunofixation electrophoresis Targeted mass spectrometry Multiple myeloma M-protein 
ProteomicsIdentification of cellular proteins interacting with PEDV M protein through APEX2 labeling
Membrane (M) proteins of coronaviruses are the most abundant component of the virus envelope and play crucial roles in virus assembly, virus budding and the regulation of host immunity. To understand more about these functions in the context of PEDV M protein, forty host cell proteins interacting wi...
ORGANISM(S): Sus Scrofa Scrofa 
2021-03-07 | PXD024559 |
ProteomicsMass spectrometry provides a highly sensitive non-invasive means of sequencing and tracking M-protein levels in blood of multiple myeloma patients
De nove sequencing of NISTmAb and of an M-protein from an multiple myeloma patient, MM2232
ORGANISM(S): Homo sapiens (Human) 
2021-07-16 | PXD022784 | Pride
Multiple myeloma M-protein 
ProteomicsN-linked glycosylation of the M-protein variable region: Glycoproteogenomics reveals a new layer of personalized complexity in multiple myeloma.
Multiple Myeloma (MM) is a plasma cell malignancy characterized by a monoclonal expansion of plasma cells that secrete a characteristic M-protein. This M-protein is crucial for diagnosis and monitoring of MM in the blood of patients. Recent evidence has emerged that N-glycosylation of the M-protein ...
ORGANISM(S): Homo sapiens (Human) 
2023-06-09 | PXD040718 | Pride
Glycoproteomics Glycoproteogenomics M-protein Multiple myeloma 
GenomicsMycoplasma genitalium and M. pneumoniae induce a distinct set of protein-coding genes in epithelial cells.
Mycoplasma genitalium and M. pneumoniae induce a distinct set of protein-coding genes in epithelial cells.
PRJNA742024 | ENA
ProteomicsDirect lipid interactions control SARS-CoV-2 M protein conformational dynamics and virus assembly
M is the most abundant structural membrane protein in coronaviruses and is essential for the formation of infectious virus particles. SARS-CoV-2 M adopts two conformations, Mshort and Mlong, and regulated transition between states is hypothesized to coordinate viral assembly and budding. However, th...
ORGANISM(S): Severe acute respiratory syndrome coronavirus 2 Homo sapiens (Human) 
2026-07-09 | PXD079401 | Pride
Hdxms Sars-cov-2 Lipid interaction 
ProteomicsDynamic profiling of the protein life cycle in response to pathogens (protein)
Protein expression is regulated by production and degradation of mRNAs and proteins, but their specific relationships remain unknown. We combine measurements of protein production and degradation and mRNA dynamics to build a quantitative genomic model of the differential regulation of gene expressio...
ORGANISM(S): Mus musculus 
2015-03-06 | E-GEOD-59792 | biostudies-arrayexpress
TranscriptomicsDistribution of Arp4 in G2/M phase
The actin-related proteins (ARPs) comprise a conserved protein family. Arp4p is found in large multisubunits of the INO80 and SWR1 chromatin remodeling complexes and in the NuA4 histone acetyltransferase complex. Here we show that arp4 (arp4S23AD159A) temperature-sensitive cells are defective in G2/...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-11 | E-GEOD-7276 | biostudies-arrayexpress
MetabolomicsSerum protein N-glycosylation changes in multiple myeloma

BACKGROUND: Multiple myeloma is characterized by clonal proliferation of malignant plasma cells in the bone marrow that produce monoclonal immunoglobulins. N-glycosylation changes of these monoclonal immunoglobulins have been reported in multiple myeloma, but previous studies on...

2022-04-27 | MTBLS676 | MetaboLights
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